Best Choline Supplement

While choline isn’t the most well-known vitamin available on the market, it’s an important nutrient, nonetheless. Most of us get enough choline through foods like eggs, liver, and beef, but some people can benefit from taking a choline supplement. Pregnant women, aging populations, and biohackers looking to boost their cognitive function are prime candidates for a choline supplement. It also can help with liver detoxification.

Double Wood Supplements CDP Choline

Double Wood Supplements Berberine

  • SUPPORTS HEALTHY CHOLINE LEVELS – CDP Choline is a potent and cost effective way to support healthy choline and acetylcholine levels.
  • SUPPORT MEMORY – CDP Choline helps support one’s ability to learn information with greater ease, retain more of what you learn, and recall memories quicker.
  • SUPPORT COGNITIVE FUNCTION – CDP Choline supports working memory, motivation, and problem solving ability
  • MADE IN THE USA – Our CDP Choline is manufactured right here in the US

CDP Choline is a potent and cost effective way to supplement your choline intake. Choline is a water soluble nutrient which acts as a precursor to the neurotransmitter acetylcholine. Acetylcholine plays an important role in many cognitive processes including memory, intelligence, and mood.

A conservative dosage estimate when taking CDP Choline as a general nootropic supplement is to take 1-2 300mg capsules in the morning. This dosage can be repeated in the afternoon if necessary. While there is no real consensus on an optimal dose, and no health organizations have provided any dosage guidelines it is generally not recommended to exceed a dosage of 1200 mg per day.

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Optimal Choline Complex

Pure Nootropics’ Optimal Choline Complex combines two products to provide superior results. The two main ingredients are CDP Choline and Alpha GPC Choline.

Pure Nootropics’ Optimal Choline Complex combines two products to provide superior results. The two main ingredients are CDP Choline and Alpha GPC Choline. Both CDP Choline and Alpha GPC are essential nutrients which are precursors to acetylcholine. Acetylcholine is a neurotransmitter in the parts of the brain that impact memory and learning, attention, and alertness–making it one of the most beneficial neurotransmitter compounds for overall cognitive function and brain health (1).

Optimal Choline Complex Benefits

1)  CDP Choline (also known as citicoline) is an essential nutrient and precursor to creating the neurotransmitter acetylcholine (1).

Some benefits of CDP Choline include: 

  • Supports cognitive function in the elderly 
  • May improve attentional performance 
  • May limit excitotoxicity from glutamate activity 
  • Promotes an increase in brain energy through improved mitochondrial function

2) Alpha GPC Choline, an abbreviation for Alpha-glycerylphosphorylcholine, is also a cholinergic compound found in the brain and a precursor to creating acetylcholine, functioning similarly to CDP Choline in acetylcholine synthesis. Alpha GPC provides some additional advantages by increasing acetylcholine in the central nervous system and seems to be the more efficient choline precursor because of its bioavailability (2).

Some benefits of Alpha GPC include:

  • Supports cognitive function in the elderly with high doses more significantly than CDP Choline 
  • May increase the production of the human growth hormone (HGH or somatropin) by working with the pituitary gland
  • Promotes increases in strength outputs during resistance training workouts 
  • May enhance lower body muscle performance 
  • May provide a steadier level of choline in the body than with CDP Choline 

Optimal Choline Complex Mode of Action

Citicoline and Alpha GPC are both involved as acetylcholine precursors. Both cholinergics combine to provide superior cognitive support in Optimal Choline Complex.

Citicoline can be produced from choline already present in the body, but choline’s ability to engage in cell membrane formation (phospholipid synthesis) is incomplete without first being converted to Citicoline.  This constant demand for choline conversion to citicoline can mean that supplementing with Citicoline itself provides a boost for overall cell functioning (1).

Choline supports memory and cognitive function and can possibly maintain overall wellness in the brain when faced with cognitive decline (2).  CDP Choline may improve attentional performance and focus (3,4).  While CDP Choline is found in dietary sources such as animal-based products, eggs, whole grains, cruciferous vegetables, nuts and seeds, most people don’t get an adequate intake of choline in their diet (1).

Being a choline, Alpha GPC is found in many of the same dietary sources that contain CDP Choline (animal-based products, eggs, whole grains, cruciferous vegetables, nuts, and seeds) and is also a nutrient that is difficult to reach an adequate level from diet alone (1).

By working directly with the pituitary gland, Alpha GPC may increase the production of the human growth hormone (2).  Preliminary trials relating to Alpha GPC administered to healthy volunteers prior to resistance exercise have shown promise in possibly increasing strength output during workouts, presumably due to its influence on HGH (4).

A clinical trial of Alpha GPC demonstrated that it may enhance lower body muscle performance related to isometric exercise (5).

Being a highly available form of choline, Alpha GPC may provide a steadier level in the body than supplementation with CDP (Citicoline).  Levels increase slowly but remain elevated longer than with Citicoline in clinical trials (6).

Optimal Choline Complex Dosage

Pure Nootropics’ Optimal Choline Complex capsules provide 200 mg of Citicoline and 100 mg of Alpha GPC.  Suggested use of Optimal Choline Complex capsules for adults is 1 capsule by mouth up to two times per day, with or without food, or as directed by your healthcare practitioner.

No daily value has been established for Alpha GPC or CDP (citicoline).  However, RDA (Recommended Daily Allowance) of Choline ranges depending on gender and age. *

  • RDA for Choline for adult men over 18 is 550 mg/day (11)
  • RDA for Choline for adult women is 400-425 mg/day (11)

 (Women who are pregnant, lactating, and children under the age of 18 should seek medical advice from a healthcare provider regarding their RDA of Choline.)

Optimal Choline Complex Side Effects and Toxicity

Side effects from short-term use of Citicoline are generally mild. Studies conducted have mostly been on a short-term basis, and as such, the safety of long-term use is not known.

Please consult your healthcare practitioner if you are taking any medications prior to beginning supplementation with Citicoline. Do not use if you are pregnant or nursing.

In both preclinical toxicological studies and clinical studies, research shows that toxicity derived from Citicoline is extremely difficult to achieve (8).

As with Citicoline, the safety of long-term use of Alpha GPC is not known.  It is generally well-tolerated, but as with all supplements and medications, some people may experience side effects.  It is considered possibly safe and side effects from Alpha GPC are mild and could include heartburn, nausea, vomiting, insomnia or excitation, and headache (9,10).

Toxicity information for Alpha GPC has been extrapolated from animal studies and demonstrates that the “No Observed Adverse Effect Level” (NOAEL) for humans was for a dose at least 150 mg/kg over a six-and-half month timespan (12).

For further information, please see our References Tab above.

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CDP Choline (Citicoline) Capsules

CDP Choline, an abbreviation of cytidine-5′-diphosphocholine, referred to as Citicoline, is an essential nutrient and precursor for the neurotransmitter acetylcholine. It is an efficient source of choline that supports overall brain health, memory function, and mental energy.

CDP Choline Benefits

  • Supports cognitive function in the elderly 
  • May improve attentional performance 
  • May limit excitotoxicity from glutamate activity 
  • Promotes an increase in brain energy through improved mitochondrial function

Citicoline plays a large role in memory formation.  A decline in cognitive memory functioning associated with aging may improve with supplementation of Citicoline (1)(6).

There is some evidence suggesting CDP choline may improve attentional performance in young adults (2).

CDP Choline may improve cerebral blood flow to the brain (7) and has the potential to decrease the accumulation of glutamate, which in excessive amounts is implicated in neurodegeneration (4).  Glutamate is a nonessential amino acid which is an excitatory neurotransmitter (8).

CDP Choline promotes an increase in brain energy through improved mitochondrial functions (4).  Mitochondria are the cell organelles that breakdown the food we eat and turn it into energy (or ATP) for the body (9).  Citicoline improves energy in three ways within the cell:  maintaining levels of phospholipids in the mitochondrial membranes, restoring ATPase activity and preventing the release of arachidonic acid from cell membranes (an oxidative stress to the body) (4).

CDP Choline Mode of Action

CDP choline is an essential nutrient and precursor to creating the neurotransmitter acetylcholine. Acetylcholine is a neurotransmitter in the parts of the brain that impact memory and learning, attention, and alertness–making it one of the most beneficial neurotransmitter compounds for overall cognitive function and brain health (4).  Citicoline is 18.5 % choline by weight (15).

Citicoline can be produced from choline already present in the body, but choline’s ability to engage in cell membrane formation (phospholipid synthesis) is incomplete without first being converted to Citicoline.  This constant demand for choline conversion to citicoline can mean that supplementing with Citicoline itself provides a boost for overall cell functioning (4).

Citicoline provides the body with choline and produces uridine as it converts into acetylcholine.  Uridine is a substrate in the Kennedy cycle which is necessary to complete the cycle and stimulates the production of phospholipid synthesis (14).

Though choline can be found in food, less than 10% of adults in the United States are reaching the recommended daily amount.  CDP Choline (Citicoline) itself is only appreciably present in a limited amount of foods such as organ meats and liver. Supplementing with Citicoline, rather than choline, provides the body with enough choline to carry out its functions in the nervous system (4).

Common dietary sources of choline are animal-based products, dairy products, whole grains, cruciferous vegetables, nuts and seeds (5).

CDP Choline Dosage

Pure Nootropics’ CDP Choline Capsules provide 300 mg of Cognizin® Citicoline. Suggested use of CDP Choline capsules for adults is 1 capsule by mouth up to two times per day, or as directed by your healthcare practitioner.

No daily value has been established for Citicoline, however the RDA (Recommended Daily Allowance) of Choline ranges depending on gender and age.*

  • RDA for Choline for adult men over 18 is 550 mg/day (13)
  • RDA for Choline for adult women is 400-425 mg/day (13)

(Women who are pregnant, lactating, and children under the age of 18 should seek medical advice from a healthcare provider regarding their RDA of Choline.)

CDP Choline Side Effects and Toxicity

Side effects from short-term use of Citicoline are generally mild. Studies conducted have mostly been on a short-term basis, and as such, the safety of long-term use is not known. It is generally well-tolerated, but as with all supplements and medications, some people may experience side effects.  It is considered possibly safe and side effects could include bradycardia, tachycardia, vomiting, nausea, or hypotension (12).  Note:  There may be pharmaceutical medications which interact with Citicoline and should not be taken together.  Please consult your healthcare practitioner if you are taking any medications prior to beginning supplementation with Citicoline. Do not use if you are pregnant or nursing.

In both preclinical toxicological studies and clinical studies, research shows that toxicity derived from Citicoline is extremely difficult to achieve (10)(11).

Double Wood Supplements Alpha GPC Choline

Alpha GPC Choline Supplement (Beginner Nootropic for Brain Support, Focus, Memory, Motivation, and Energy) Pharmaceutical Grade, Made in USA (60 Capsules 300mg)

Double Wood Supplements Alpha GPC Choline provides 600mg of choline per serving. The serving size is two tablets.

  • PROMOTE CHOLINE LEVELS – Alpha GPC is a highly bioavailable form of Choline which helps support healthy Choline levels
  • SUPPORT YOUR MEMORY – Remember more information for your exams, forget less deadlines at work, no more losing your car keys
  • SUPPORT ACETYLCHOLINE SYNTHESIS- Nootropics supplement to support memory, focus, and acetylcholine levels
  • MADE IN THE USA – Our Alpha GPC is manufactured right here in the USA
  • SAFETY TESTED IN THE USA – Double Wood’s Alpha GPC is safety tested for heavy metals and microbes in New York
  •  

According to the American College of Nutrition up to 90% of Americans are deficient in choline and it is recommended to supplement with a choline product. Alpha GPC is the most bioavailable form of Choline. This means it crosses the blood brain barrier more easily than other choline supplements and is most effective and replenishing choline levels. Optimizing choline levels may lead to improved cognitive function and increased motivation. Double Wood Supplement’s Alpha GPC is manufactured in New York city and tested for purity right here in the USA.Please note this product is derived from soy and those with a soy allergy should not consume it.

 

Safety Information
Consult your physician before using this product. Do not consume more than 4 capsules per day. Do not take this product if you are pregnant, nursing, or taking any other medications. Discontinue use and consult your doctor immediately if any adverse reactions occur. Do not take Alpha GPC and operate any heavy machinery until you know how it affects you. Keep out of reach of children. Do NOT take if you have a Soy Allergy. Side effects include fatigue, headaches, nervousness, nausea, diarrhea, and GI problems.

Indications
ALLERGEN NOTICE: SOY, NON-GMO and GLUTEN FREE. Side effects include fatigue, headaches, nervousness, nausea, diarrhea, and GI problems.

Ingredients
Active Ingredients: Alpha GPC – 300mg, Other Ingredients: Gelatin, Cellulose, Silicon Dioxide

Directions
Take 1-2 capsules (300-600mg) per day (with food) to support cholinergic brain function and cognitive function.

Legal Disclaimer
Statements regarding dietary supplements have not been evaluated by the FDA and are not intended to diagnose, treat, cure, or prevent any disease or health condition.

Bulksupplements Pure Choline DL-Bitartrate Powder

  • Provides 750mg of choline per serving
  • Contains no additives
  • Gluten-free
  • Sugar-free
  • Lab-tested for purity
  • Boosts athletic endurance and Assists in muscle recovery*
  • Antioxidant and Promotes heart health*
  • Helps support the liver and Aids in maintaining healthy weight*
  • Supports memory & brain function*
  • Contributes to overall health & wellness*

Size:100 Gram (3.5 Ounce) Powder
What is Choline Bitartrate?

Choline bitartrate is the salt form of choline, an essential nutrient found in food and supplements. It helps the body stabilize choline and turns it into acetylcholine, a neurotransmitter essential to learning and memory, and lecithin, a fat essential to cells in the body. Choline is an essential nutrient necessary for proper body function. Even though it is not actually a B vitamin, it is sometimes considered to be a part of this complex because it operates in conjunction with various types of B vitamins to maintain adequate levels of health in the body.

This is the Choline DL-Bitartrate variant.

Choline Bitartrate Benefits
Choline bitartrate is most commonly used to help boost athletic endurance and help with muscle recovery.* It supports liver and heart health and may assist in maintaining healthy weight when taken in conjunction with a healthy diet and exercise.* Choline bitartrate may help support memory and the brain.* It may also act as an anti-inflammatory and antioxidant.*

Safety Information
*Always consult your health care provider before taking any supplements. Pregnant or lactating women, people with existing medical conditions, or people taking medications should consult their health care provider/s before taking any dietary supplement. If you experience any adverse condition after taking this dietary supplement, discontinue use immediately and consult your health care provider. Keep out of reach of children.

Ingredients
Other ingredients: None

Legal Disclaimer
*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Statements regarding dietary supplements have not been evaluated by the FDA and are not intended to diagnose, treat, cure, or prevent any disease or health condition.

Frequently Asked Questions About Choline Supplements

What is Choline?

Choline is a vitamin-like essential nutrient. Getting enough choline in your daily diet can help to prevent high homocysteine levels in your blood. A high level of homocysteine is known to increase the risk of stroke, heart attack, cancer, and dementia.

Choline is an essential nutrient. Although the body is able to synthesize very small amounts of choline, it must be obtained from the diet to maintain healthy levels. Most of the choline in the human body is found in fat molecules called phospholipids.

Lecithin is a phospholipid and is the most abundant of all of them. The structure of every single cell in the human body is made up of this fatty substance. It is essential for the proper functioning of the brain and the nervous system.

Lecithin is also a vital component of the heart muscles and the endocrine glands, and it makes up more than half of the total fat in the liver. Over-activity of the nervous system or glands will use up stores of lecithin more quickly than it can be replaced. If this happens, you will be left feeling exhausted and irritable.

Lecithin also helps the brain by improving memory. It is also responsible for boosting the effects of vitamin E, keeping the skin soft, smooth and young-looking, keeping the heart muscles in tone and good circulation.

Cholesterol and fats obtained from the diet are transported, by lipoproteins, to the liver. There they are transformed into low-density lipoproteins and transported through the blood steams to tissues where they are needed. Choline is essential for this process. Without choline cholesterol and fat would just build up in the liver. Important choline sources include liver, fish, beans eggs, dairy products, and soy foods.

What Are the Uses & Benefits of Choline?

A choline supplement is often recommended for its numerous health benefits. Choline benefits include:

  • DNA: Choline is involved in the process of fat absorption and the production of cell membrane structure. Insufficient choline prevents cells from maintaining their proper structure and transmitting signals. Choline is required for gene expression and to produce DNA. Combined with folate, choline is also involved in methyl group processes, which create genetic material throughout the body.
  • Central nervous system: Choline is essential for healthy nerve functioning. It assists in brain development and growth. It is possible that choline can improve nerve signaling capacity and protect neuronal membranes. Choline is a precursor to the neurotransmitter acetylcholine, which is essential for healthy nerve and muscle function. Acetylcholine plays an important role in memory and learning. Sufficient choline is required to prevent poor concentration, poor memory, and mood swings.
  • Liver function: Choline is required for the transportation of cholesterol and triglycerides from the liver. Insufficient choline can result in a build-up of lipids in the liver causing fatty liver disease.
  • Inflammation: Preliminary research shows that choline has the ability to inhibit the body’s inflammatory response factors. More studies are needed.
  • Alzheimer’s and Parkinson’s disease: Initial trials suggest that choline may help to improve the symptoms of people suffering from mild Alzheimer’s disease. It may also alleviate symptoms such as stiffness and trembling in the body’s extremities caused by Parkinson’s disease.
  • Athletic performance: In a study published in the Journal of the International Society of Sports Nutrition, a single 600mg dose of choline take 90 minutes before a resistance workout increased athletic performance. More research is needed.
  • Pregnancy: The body’s need for choline may increase during pregnancy. Studies have been conducted to examine the relationship between maternal choline levels and the risk of neural tube defects, however, the results were inconsistent. More research is needed.
  • Stroke: Recent studies suggest that taking a supplement of citicoline (a choline derivative) may limit neurologic damage in stroke patients. More research is needed.

How Do I Take Choline?

There is no standard recommended choline dosage. Most nutritional experts agree on the following suggested choline supplement dosage:

  • Adults: 425- 550mg
  • Pregnant women: 450-550mg
  • Breastfeeding women: 550mg

Are There Any Side Effects of Choline?

Choline is considered to be safe when taken orally in the manufacturer’s suggested amounts. High doses above 3.5 grams are considered to be possibly unsafe. Possible side effects include upset stomach, sweating, diarrhea, and vomiting.

You should not take a choline supplement if you are taking Atropine as it may interfere with the effectiveness of this medication.

How Do I Pick a Good Choline Product?

When you’re looking for a good choline supplement, choose one that contains CDP choline. This is also sometimes called Alpha GPC choline, or Citicoline. This is the most potent form of choline and provides the most health benefits.

You should also choose a choline supplement that is non-GMO, made with organic ingredients and contains no common allergens, artificial sweeteners, colors or flavors, or fillers.

Choline-Bundle-1-650x650

Choline Bundle

Included in our discounted Choline Bundle is the following:

  • Alpha GPC 60 x 300 mg capsules
  • Cognizin® CDP Choline (Citicoline) 60 x 300 mg capsules
  • Choline Bitartrate (VitaCholine®) 60 x 300mg capsule
  • Optimal Choline Complex 60 x 300 mg capsules

Optimal Choline Complex

Pure Nootropics’ Optimal Choline Complex combines two products to provide superior results. The two main ingredients are CDP Choline and Alpha GPC Choline.

Some benefits of CDP Choline include: 

  • Supports cognitive function in the elderly 
  • May improve attentional performance 
  • May limit excitotoxicity from glutamate activity 
  • Promotes an increase in brain energy through improved mitochondrial function

Some benefits of Alpha GPC include:

  • Supports cognitive function in the elderly with high doses more significantly than CDP Choline 
  • May increase the production of the human growth hormone (HGH or somatropin) by working with the pituitary gland
  • Promotes increases in strength outputs during resistance training workouts 
  • May enhance lower body muscle performance 
  • May provide a steadier level of choline in the body than with CDP Choline 

Choline Bitartrate (VitaCholine®) Capsules

Choline is an essential nutrient and precursor for the neurotransmitter acetylcholine. Choline Bitartrate is a highly stable, cost-effective and bioavailable form of choline and has been branded under VitaCholine® which is naturally sourced from only natural tartaric acid from wine production (1)(9).

  • Promotes increased choline level 
  • May improve visuomotor performance 
  • Highly bioavailable form of choline 
  • GRAS 

Alpha GPC 50% Capsules & Powder

  • Supports cognitive function in the elderly at high doses 
  • May increase the production of the human growth hormone (HGH or somatropin) by working with pituitary gland 
  • Promotes increases in strength outputs 
  • May enhance lower body muscle performance 

CDP Choline (Citicoline) Capsules

CDP Choline, an abbreviation of cytidine-5′-diphosphocholine, referred to as Citicoline, is an essential nutrient and precursor for the neurotransmitter acetylcholine. It is an efficient source of choline that supports overall brain health, memory function, and mental energy.

  • Supports cognitive function in the elderly 
  • May improve attentional performance 
  • May limit excitotoxicity from glutamate activity 
  • Promotes an increase in brain energy through improved mitochondrial function
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