Best PQQ Supplements

PQQ also has a number of other important roles within the body’s cells. However, one that is considered high priority is its role in the development of mitochondria. Mitochondria are tiny specialized structures that reside in each of the body’s cells. They are responsible for powering the cell, rather like a battery. PQQ not only activates the growth of mitochondria, but it also protects them from oxidative stress.

Double Wood Supplements PQQ (Pyrroloquinoline quinone)


  • SUPPORTS CARDIOVASCULAR HEALTH – Research has shown PQQ may be beneficial for supporting a healthy cardiovascular system.
  • SUPPORTS COGNITIVE HEALTH – Studies have shown PQQ may support cognitive health due to its neuroprotective properties.
  • PROMOTES MITOCHRONDRIAL BIOGENESIS – PQQ promotes the biogenesis of cellular mitochondria as well as supporting their efficiency at energy production.
  • MADE IN THE USA – Our PQQ is manufactured right here in the USA at a cGMP certified facility.

PQQ (Pyrroloquinoline quinone) is a small quinone molecule which acts as a REDOX agent, allowing it to reduce oxidants before being recycled back into an active form by glutathione, making it capable of acting again as an antioxidant.

The main benefit of PQQ supplementation is its ability to support the production and effective function of mitochondria, which play the key role of converting nutrients into energy which can be used by cells. There is also research suggesting PQQ may be beneficial for supporting cardiovascular and cognitive health.

As a supplement for cognitive, cardiovascular, or mitochondrial health we recommend taking a dosage of 20 – 40 mg (1-2 capsules) per day on an empty stomach. It is not recommended to take a dose exceeding 80 mg (4 capsules) per day.


PQQ (Pyrroloquinoline quinone) Capsules

PQQ (Pyrroloquinoline quinone) is a small bioactive, non-vitamin compound which acts as a REDOX (reduction-oxidation) agent and supports mitochondrial function (1).

PQQ (Pyrroloquinoline quinone) Benefits

  • Supports mitochondrial function 
  • Promotes cognitive function while aging 
  • May improve sleep quality 
  • Promotes healthy cholesterol levels 

PQQ (Pyrroloquinoline quinone) is emerging as a subject of interest in the medical community, but thus far, there has not been a large amount of research or trials conducted with humans, except for those studies referenced above.*

The following are examples of dynamics associated with PQQ (Pyrroloquinoline quinone) through the animal model and may not be representative of the effects in the human body:

  • May reduce oxidative stress (in rats)

PQQ (Pyrroloquinoline quinone) Mode of Action

PQQ is a quinone molecule that is found in food sources and mammalian tissue.  The highest food sources are fermented soybeans (natto), spinach, green soybeans, field mustard, tofu, green tea, green peppers, kiwi fruits, parsley, and human breast milk (1).

PQQ acts as a REDOX agent by reducing oxidants and is recycled back into glutathione (the master antioxidant).  PQQ can be recycled many thousands of cycles before the end of its function.  It was first believed to be a vitamin but is now regarded as a bioactive non-vitamin compound (1).

Other common REDOX agent supplements include Vitamin C and alpha-lipoic acid.  PQQ works by its modification of REDOX proteins in the cell (1).

PQQ is chemically neuroprotective and regulates a glutamate receptor, NMDA, by inhibiting overexertion of the NMDA signals which can be toxic to the brain.  PQQ injected into the brain is accepted as a neuroprotectant, but it is not clear if oral supplementation carries the same benefit (1).

PQQ protects mitochondria in two ways: first, it maintains mitochondrial mass.  Research in vitro has demonstrated that PQQ preserves mitochondria by reducing oxidative stress and inhibiting the death of cells (1). Secondly, it appears from research in animals that PQQ can stimulate mitochondrial regeneration by stimulating phosphorylation of a cAMP response element-binding protein (CREB) and activating the promotion of a pathway for PGC-1a which is known to control mitochondrial biogenesis (2).

PQQ supports cognitive function in compromised populations, such as the elderly or those individuals with a cognitive impairment, rather than in healthy individuals (1).

PQQ (Pyrroloquinoline quinone) Dosage

Pure Nootropics PQQ provides 20 mg per 1 capsule.  Suggested use for adults is 1 capsule by mouth daily with a meal.

If you are taking any medications, always consult with you Healthcare Practitioner before beginning any new supplement.

PQQ (Pyrroloquinoline quinone) Side Effects & Toxicity

PQQ is a fairly new supplement and there are few long-term clinical trials detailing the effects on humans.

In rats, PQQ is associated with kidney and liver toxicities, but a consumption of 20 mg for a 150 lb human during a one-week period has been determined to be safe. It is best to not “superload” this supplement until further research is available (1).

In rats, PQQ was determined to have a No Observed Adverse Effect level of 100mg/kg bodyweight/day.  A toxic dose was achieved in male rats at 1000-2000 mg/kg bodyweight and at 500-1000 mg/kg bodyweight/day in female rats (3).

Jarrow Formulas PQQ

Jarrow Formulas Pyrroloquinoline Quinone, Supports Heart and Cognitive Function, 20 mg, 30 Caps

  • Promotes mitochondrial biogenesis
  • Supports heart and cognitive function
  • No wheat, no gluten, no soy, no dairy, no egg, no fish/shellfish, no nuts/tree nuts

Jarrow Formulas PQQ, 20 Milligrams, 60 Capsules. Pack of 1 bottle. What Does PQQ Do: PQQ (pyrroloquinoline quinone) is an important antioxidant that promotes the creation of new mitochondria, along with supporting heart health and cognitive function. For superior benefits, take with Jarrow Formulas QH-absorb. Suggested Usage: Take 1 capsule per day or as directed by your qualified healthcare professional. Ingredients: BioPQQ (pyrroloquinoline quinone) 20 milligrams. Other Ingredients: Cellulose, magnesium stearate (vegetable source) and silicon dioxide. Capsule consists of gelatin. No wheat, no gluten, no soybeans, no dairy, no egg, no fish/shellfish, no peanuts/tree nuts

Safety Information
NOTE: If you have a medical condition, are pregnant, lactating, trying to conceive, under the age of 18, or taking medications, consult your healthcare professional before using this product.This product is labelled to United States standards and may differ from similar products sold elsewhere in its ingredients, labeling and allergen warnings

BioPQQ (Pyrroloquinoline quinone disodium salt), Cellulose, magnesium stearate (vegetable source) and silicon dioxide. Capsule consists of gelatin.

Take 1 capsule per day or as directed by your qualified healthcare professional.

Legal Disclaimer
Statements regarding dietary supplements have not been evaluated by the FDA and are not intended to diagnose, treat, cure, or prevent any disease or health condition.

Doctor’s Best PQQ

Doctor’s Best PQQ with BioPQQ, Non-GMO, Vegan, Gluten Free, Soy Free, 20 mg, 30 Veggie Caps (DRB-00295)

  • Authentic, pure pyrroloquinoline quinone
  • No Gluten, Non-GMO, Vegan
  • 30 Caplets
  • 1 Month Supply
  • Label Images May Vary

Doctor’s Best PQQ with BioPQQ provides pyrroloquinoline quinone (PQQ). PQQ is a polyphenol with antioxidant properties that’s important for energy production and supports nerve cells and cognitive functions.*

PQQ also stimulates the growth of new mitochondria even in aging cells. Mitrochondria are the cell’s power producers, generating about 90% of the energy for physical and mental functions.*

What are the benefits of PQQ?

  • Helps support mitochondrial biogenesis and function*
  • Helps support cardiovascular health and cellular energy *
  • Helps support cognitive functions *

Why take PQQ?

  • Regulates cell development, cell signaling, even gene functions. *
  • Shown to prevent oxidative stress, mitochondrial dysfunction and cell death in cardiac muscle cells.*
  • Has important properties in cell signaling and as an antioxidant.*

How does it work?

  • Promotes mitochondrial biogenesis and survival and energy production.*
  • BioPQQ contains pyyroloquinoline quinone, a polyphenol nutrient that is an antioxidant and cell regulator.*
  • It has roles in antioxidant protection and as an essential cofactor for a variety of enzymes.*
  • PQQ’s capacity for ‘redox cycling’ is likely the foundation for its unique actions in living systems. *

Best PQQ featuring PQQ supplies pyrroloquinoline quinone (PQQ), a polyphenol that is an exceptionally potent antioxidant and cell regulator. PQQ is found in common foods and human milk, and is a growth factor for the mitochondria that generate over 90 percent of our life energy. PQQ promotes mitochondrial survival, proliferation, and function. Doctor’ s best is pleased to provide the most bioactive PQQ at full clinical potency.


Frequently Asked Questions About PQQ Supplements

What is PQQ?

Termed by some manufacturers as “the other CoQ10,” pyrroloquinoline quinone (PQQ), is a quinone molecule which is also a redox cofactor – this means it has antioxidant effects, after which it returns to its previous active form. It is capable of cycling through this process several thousands of times before it is used up. In this, it is unique.

PQQ was discovered in 1979 by J.G. Hauge. It was the third redox cofactor to be discovered. Redox cofactors are a vital component of the human metabolic process. PPQ’s role is to trigger cell signal pathways involved in the metabolism of energy, helping the body transport energy obtained from food.

PQQ also has a number of other important roles within the body’s cells. However, one that is considered high priority is its role in the development of mitochondria. Mitochondria are tiny specialized structures that reside in each of the body’s cells. They are responsible for powering the cell, rather like a battery. PQQ not only activates the growth of mitochondria, but it also protects them from oxidative stress.

The discovery of PQQ led to many channels of clinical research, including the biological significance of PQQ, investigations on other enzymes that interact with these molecules, and how PQQ can be used in the treatment of disease.

As well as the human body, PQQ can also be found in soil and foods such as kiwifruit, bananas, cabbage, potatoes, carrots, tofu, spinach, parsley, and egg yolk. It is also found in skim milk, green tea, oolong tea, and sake.

What Are the Uses & Benefits of PQQ?

A considerable amount of research has been conducted on pyrroloquinoline quinone benefits.

  • Metabolism: It was already known that dietary pyrroloquinoline quinone has effects on energy-related metabolism and brain functions in animals. In a cross-over study published in 2013 in the Journal of Nutritional Biochemistry, the effects of dietary pyrroloquinoline quinone were tested on humans. In this study, ten subjects were given PQQ in a drink in either a single dose of 0.2mg PQQ/kg or 0.3mg PQQ/kg. Changes in PQQ levels in urine and plasma were measured, as changed in antioxidant potential. The results showed that supplemental PQQ has positive effects on inflammation and mitochondrial metabolism in humans.
  • Fatigue: A 2012 study published in Functional Foods in Health and Disease was designed to test the effects of pyrroloquinoline quinone on fatigue, stress, and quality of sleep. In the trial, 17 adult subjects were given 20mg of pyrroloquinoline quinone each day for eight weeks. The results showed that PQQ improved sleep onset, quality of sleep, and reduced sleepiness on awakening. The same study also revealed some pain relief in the subjects.
  • Antioxidants: A preliminary animal study published in 2010 in the Journal of Biological Chemistry showed that pyrroloquinoline quinone may create new mitochondria and provide added protection from free radicals by increasing the internal production of antioxidants. More research is needed.
  • Memory: A 2008 animal study published in the Journal of Clinical Biochemical Nutrition, suggested that PQQ may prevent memory loss caused by oxidative stress. More research is needed.
  • Methylmercury toxicity: Methylmercury is a highly toxic form of mercury that is formed when bacteria reacts with mercury in plants, water, or soil. It was once used as a preservative for animal grain feed. It is still used in batteries, fluorescent lights, and polyvinyl chloride, which is used to make plastic pipes, sheeting, and flooring. Methylmercury poisoning can damage the brain and nervous system. A 2009 study published in Free Radical Research, showed that PQQ can offer protection against methylmercury toxicity.

Many PQQ supplement manufacturers claim that PQQ can help protect against Alzheimer’s and Parkinson’s, protect against stroke, help improve obesity and help protect the heart. There is no clinical evidence to support these claims.

How Do I Take PQQ?

There is no standardized PQQ supplement dosage. However, based on trials, effective PQQ dosage could be as low as 2mg. The suggested dosage for most pyrroloquinoline quinone dietary supplements is within the range of 20-40mg.

Are There Any Side Effects of PQQ?

PQQ is generally considered safe when taken orally in the suggested doses for short periods of time. It is possible that taking high doses over PQQ over an extended period of time may cause damage to the liver and kidneys.

Because of the lack of available information, you should not take PQQ if you are pregnant or breastfeeding.

There is currently no available information about PQQ’s interaction with other drugs.

How Do I Pick a Good PQQ Product?

The higher quality pyrroloquinoline quinone supplements should have a potency of around 20mg. An effective pyrroloquinoline quinone should be non-GMO, free from common allergens, gluten, unnecessary fillers, and artificial additives. It should also be suitable for vegetarians and vegans.

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