Best Sulbutiamine Capsules

Sulbutiamine is a synthetic derivative of thiamine. In France, it is used to treat symptoms of weakness or fatigue. It is also sold as a dietary supplement. Sulbutiamine was discovered in Japan as part of an effort to develop useful thiamine derivatives.

41AdNsg6xiL

Sulbutiamine Capsules

Sulbutiamine is a derivative of Thiamine (Vitamin B1) that was first synthesized in Japan in the 1950s (1)(2).

May reduce fatigue 
May help with recovery after illness 

Sulbutiamine is a subject of interest in the medical community, but thus far, there has not been a large amount of research or trials conducted with humans, except for some studies referenced above.*

 The following are examples of dynamics associated with Sulbutiamine through the animal model and may not be representative of the effects in the human body:

  • Supports memory (in mice) 
  • May improve recognition (in rats) 
  • May promote anti-oxidant activity (in vitro) 

Sulbutiamine Mode of Action

A deficiency in Vitamin B1 can cause cognitive deficits in memory and general cognition (2).  The Japanese started researching the effect of diet and Vitamin B1 in the late nineteenth century due to a high mortality rate associated with sailors.  They found that the highest incidence of Vitamin B1 deficiency was in the crew members who ate a diet of mostly white rice, and by improving the diet with a varied intake of meat and fish, barley, rice and beans, the mortality rate decreased.  Vitamin B1 deficiency is commonly linked to a diet consisting of mostly processed white rice (3).

Sulbutiamine was synthesized to be fat-soluble and has a greater bioavailability than Vitamin B1 itself (1).  Although not fully understood at this time, the benefits Sulbutiamine has for combating symptoms of fatigue is believed to be in its ability to upregulate the system involved in the sleep-wake state and fight vs. flight response. Animal research suggests that it may also work with the cholinergic, glutamatergic, and dopaminergic systems in the brain, which is believed to account for its cognitive benefits such as improving memory (4).

Sulbutiamine Capsules Dosage

Pure Nootropics’ Sulbutiamine Capsules provide 200 mg per 1 capsule.  Suggested use for adults is up to 2 capsules by mouth daily, or as directed by your healthcare practitioner.

If you are taking any medications, always consult with you Healthcare Practitioner before beginning any new supplement.

Sulbutiamine Side Effects & Toxicity

If you are taking any medications, always consult with you Healthcare Practitioner before beginning any new supplement.

A lethal dose was achieved in rats at a dose of 5 gram/kg and in mice at 5 gm/kg (5).

61IJNqvD5LL._AC_SL1000_

Power Athletes Bundle

The Power Athlete Bundle Contains the Following Products:

 

Krill Oil Softgels

Pure Nootropics’ Krill Oil Softgels provide Omega 3’s (DHA + EPA) plus Astaxanthin, a unique antioxidant specific to Krill Oil.

  • Contains Astaxanthin for superior heart health support 
  • Promotes anti-inflammatory activity in joints 
  • Supports Heart health 
  • Supports Cognitive health 
  • Supports Bone and Joint health 
  • Supports Mood 

1-2-Go

The benefits of Caffeine + L-theanine are now formulated in our 1-2-GO product to provide all the nootropic benefits of Caffeine, L-theanine and Theobromine.

Caffeine + L-Theanine Combination Benefits

  • May improve cognitive performance 
  • Promotes benefits of caffeine without unwanted effects 
  • Supports focus and attention 
  • Promotes wakefulness and alertness 
  • L-Theanine is General Recognized As Safe (GRAS) by U.S. FDA 

Theobromine Benefits

  • A naturally occurring, mild stimulant responsible for the mood enhancing effects of chocolate 

Phenylpiracetam Powder & Capsules

  • Phenylpiracetam (2-(2-Oxo-4-phenylpyrrolidin-1-yl)acetamide) is a derivative of Piracetam 
  • Synthesized in 1983 , it is fat soluble and provides superior absorption 
  • More potent than Piracetam 
  • Assured Purity: Rigorously tested for quality & purity by third-party Certificate of Analysis*
30 x 100mg Capsules
 

Sulbutiamine Capsules

Sulbutiamine is a derivative of Thiamine (Vitamin B1) that was first synthesized in Japan in the 1950s (1)(2).

  • May reduce fatigue 
  • May help with recovery after illness 

Sulbutiamine is a subject of interest in the medical community, but thus far, there has not been a large amount of research or trials conducted with humans, except for some studies referenced above.*

 The following are examples of dynamics associated with Sulbutiamine through the animal model and may not be representative of the effects in the human body:

  • Supports memory (in mice) 
  • May improve recognition (in rats) 
  • May promote anti-oxidant activity (in vitro) 
60 x 200mg Capsules

KSM-66® Ashwagandha Powder & Capsules

KSM-66® Ashwagandha is an expertly formulated extract of Ashwagandha containing the highest concentration of the root available today, created by Ixoreal Biomed after 14 years of refinement (1).

  • Mood and stress support 
  • Supports sexual health in males  and females 
  • Promotes a healthy body weight 
  • Supports cognitive health 
  • May enhance cardiorespiratory fitness 
  • May promote muscle recovery after resistance-training exercise 

*This product contains milk allergens 

90 x 300mg Capsules

Benefits & Effects

Sulbutiamine Decreases Fatigue, Improves Mood

Several extensive studies have found that sulbutiamine significantly increases energy in people who are feeling fatigued. Sulbutiamine benefits Increase energy & stamina.

was used in the treatment of 40 patients with syndrome and asthenia. Before treatment, the patients have pronounced asthenia appearances, anxiety disorders, relevant autonomic disorders, mild depression and of working capacity, attention concentration and memory. The treatment conducted as monotherapy during 28 days with dosage 400 mg/day. After treatment, expression of autonomic and asthenic disorders was reduced significantly, along with of psychometric and neurophysiological indices. High efficacy of the medication was in 75% of the patients and moderate one–in 25%.

Sulbutiamine Relieves Anxiety, Depression, and Social Avoidance

Sulbutiamine has no antidepressive effect but it can hasten the resorption of inhibition occurring during major depressive disorder and thereby facilitate the rehabilitation of patients in their social, professional and family life functioning. R

Sulbutiamine Boosts Motivation

there is some evidence that sulbutiamine increases dopamine and glutamate in your prefrontal cortex, which links to increased motivation and good mood. [R]

It has a growing number of fans in the nootropic community, many of whom report improved mood and heightened mental endurance.

Sulbutiamine for Memory

Sulbutiamine is made up of two vitamin B1 molecules attached together, which could explain its effect on memory. Vitamin B1 plays an essential role in acetylcholine synthesis in your brain. In fact, it’s the only vitamin that regulates acetylcholine levels, keeping them from getting too low or too high. [R]

What is acetylcholine?

It’s a substance found throughout your nervous system, that acts as a neurotransmitter. Your brain uses most of its acetylcholine to control your muscles, which could explain why taking sulbutiamine helps so much with fatigue. But acetylcholine also plays a key part in memory; it helps you consolidate new memories and remember old ones.” [R]

Improves Sexual Performance

Sulbutiamine treatment for 30 days restored sexual performance in 16 patients out of 20 (open-label) with erectile dysfunction (caused by psychological issues) [R]

Mechanism of Action

Sulbutiamine is a molecule which is two Thiamine (B1) molecules linking together, similar to how Pyritinol is two Pyridoxine (B6) molecules link together.

Sulbutiamine is a isobutyryl thiamine disulfide and sometimes goes by its brand names of Ereon or Arcalion. It is most commonly in use for Asthenia, or weakness (part neurological and part myopathic) as well as treatment of somatic and psychic inhibition. It doesn’t possess psychostimulant properties, although it is designed to act centrally (in the brain). [1]

Sulbutiamine synthesizes from Thiamine, where after the opening of the thiazole ring of Thiamine and dimerization to a disulfide compound it is then esterified. [2]

Sulbutiamine is a fat-soluble molecule that crosses the blood-brain barrier more readily than thiamine. Once in your brain, it increases levels of thiamine pyrophosphate (TPP). Thiamine pyrophosphate (TPP) is directly involving in the citric acid cycle in the brain.

This cycle breaks fatty acids, amino acids, and monosaccharides into smaller molecules that produce adenosine triphosphate (ATP) energy for your mitochondria. And provide the building blocks of the electrons needed to generate brain cells. [R]

Dosage

How to take: Sulbutiamine supplement recommendation dose is 400mg. However, caution is necessary in regards to cycling sulbutiamine and not supplementing on daily basis.

Sulbutiamine dosage: 200–600 mg/day, taken in the morning. Sulbutiamine is fat-soluble (in fact, that’s the reason it can pass the blood-brain barrier and have all these nootropic properties), so be sure you take it with a fat source; otherwise, you won’t absorb it. [R]

Sulbutiamine Stack

It’s quite rare to find recommendations of stacking sulbutiamine and out of all that I have come across, I think the best stack, or at least one that I would personally consider, is sulbutiamine, aniracetam, and choline stack. For example:

Sulbutiamine 200mg
Aniracetam 750mg
Alpha-GPC 300mg

Aniracetam & choline stack has been one of the most effective I have ever tried. Sulbutiamine supposedly stacks well with racetams and is a common choice due to similarities of effects on cognitive function. [R]

Side Effects

At standard doses (200–1000 mg), side effects could include a headache, nausea, and trouble sleeping.

People doing self-experiments with sulbutiamine, though, occasionally report anxiety and negative thoughts from taking higher doses (most of these side effects showed up around 1000–2000 mg). Others say they feel anxiety from taking sulbutiamine for too long without a break. [R]

Conclusion

If you decide to use sulbutiamine, be sure to cycle it. When you don’t take the occasional day off from sulbutiamine, it’s likely you’ll build a tolerance to its effects, and the sulbutiamine will stop working unless you increase the dose. [R]

Experiment is key to finding the dosage and cycle that’s just right for you and your body composition.

It’s a great choice to consider on days where you need extra mental functionality.

Sulbutiamine is becoming more and more popular in the biohacking community. If you’re curious, give it a try and see how you feel.

We will be happy to hear your thoughts

Leave a reply

2020 Best Health Products
Logo
Enable registration in settings - general
Compare items
  • Total (0)
Compare
0