Best Theacrine Extract Capsule

What is TeaCrine?

TeaCrine® is a patented theacrine from Compound Solutions. Similar to methylliberine/Dynamine® (another of their trademarked ingredients), theacrine/TeaCrine® is an isolated purine alkoloid found primarily in the kucha tea leaf and the Cupuacu fruit​2​. Its effects are basically that of a slower-onset, milder, longer-duration caffeine: enhanced mood, energy, focus, and motivation.

Double Wood Supplements Theacrine

doublewoodsupplements

  • SUPPORT ENERGY LEVELS – Theacrine helps support mental and physical energy levels.
  • SUPPORT FOCUS AND MOTIVATION – Studies have shown that Theacrine promotes one’s motivation and ability to concentrate.
  • LOW TOLERANCE – Studies have shown no tolerance forming to Theacrine even after weeks of daily use.
  • MADE IN USA – This nootropic is manufactured right here in the USA at a cGMP certified facility.

Theacrine is an energy and focus support supplement that works in a similar way to caffeine. Its primary advantage is that a tolerance to its effects builds at a much slower pace when compared to caffeine. While a caffeine tolerance begins to set in after only a few days of use, studies have shown no formation in tolerance to Theacrine even after a week of daily use.

If you’ve never used Theacrine before, we recommend starting with a dosage of one 100 mg capsule taken in the morning. If necessary, increase this dose to 200 mg. It is not recommended to exceed 400 mg of Theacrine in one day.

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Theacrine (TeaCrine®) Capsules

Theacrine (1,3,7,9-tetramethyluric acid) is found in some coffee species and tea, most notably kucha (Camellia assamica) (1). 

TeaCrine® is a registered trademark and protected by Patents Pending, Serial No. 61/903,362; under exclusive global distribution by Compound Solutions, Inc.

Theacrine (TeaCrine®) Capsules Benefits

  • May enhance energy, focus, and concentration 
  • Non-habit-forming source of energy 
  • GRAS (Generally Recognized as Safe) 
  • Combined with caffeine, supports cognitive function 
  • Combine with caffeine for greater bioavailability 

Theacrine (TeaCrine®) Capsules Mode of Action

TeaCrine® is a chemically equivalent version of theacrine (1).  Theacrine is an alkaloid molecule closely related to caffeine but structurally different.  The most abundant source of theacrine known at this time is from Kucha tea leaves (2).

The difference between theacrine and caffeine molecules is an additional methyl group and ketone group.  Like caffeine, theacrine causes signaling changes on adenosine receptors and may influence dopaminergic signaling in a similar manner to caffeine (2).

Kucha tea is a Chinese tea containing two major alkaloids, caffeine and theacrine.  Concentrations of both alkaloids are higher in younger leaves and buds and lower in mature leaves.  Research suggests that theacrine is synthesized from adenosine through caffeine in a three-step pathway within the kucha leaves (3).

Unlike caffeine, no adverse effects or changes in blood pressure or heart rate occur in animal studies (4).  Even when combined with caffeine, no differences in heart rate or blood pressure were noted in human trials (5).  In a clinical human study, all values for clinical safety markers (such as blood pressure, heart rate, lipid profiles, biomarkers of liver, kidney, and immune function, and hematologic blood counts) were normal throughout the 8-week study (1).

TeaCrine® was found to be non-habituating, unlike caffeine (1).

Theacrine (TeaCrine®) Capsules Dosage

Theacrine (TeaCrine®) Capsules provide 100 mg of Theacrine (as TeaCrine®) per 1 capsule.  Suggested use for adults is 1 capsule by mouth daily, or as directed by your healthcare practitioner.

If you are taking any medications, always consult with you Healthcare Practitioner before beginning any new supplement.

Theacrine (TeaCrine®) Capsules Side Effects and Toxicity

Theacrine (TeaCrine®) is considered GRAS by the U.S. FDA (Generally Recognized As Safe).

The lethal dose for mice was achieved at 810.6 mg/kg which equates to 4 g per a 76 kg human (4).

Theacrine 100mg as Teacrine™ - 60 Count (V-Capsules)

INSTRUCTIONS — Take one capsule with food up to five times per day. Do not exceed the recommended dose.FORMULA — Exclusively formulated with high-grade ingredients, free from any redundant fillers; vegan and gluten free.

As a dietary supplement, take one capsule of 100mg Theacrine, preferably right before or after a meal, up to four times per day.

  • Do not exceed the recommended dose of four capsules per day.
  • It can be taken at any time in the day, but is best taken in the morning as it can otherwise negatively impact sleep
  • It is best taken with food.
  • 60 Capsules / 60 Servings.
  • 100mg Theacrine per capsule.
  • 100mg Theacrine per serving.
  • 1 capsule per serving.
  • 4 servings per day, max.
Size: 60 Count (Pack of 1)
  • Shipping Weight: 2.4 ounces 
  • ASINB071NPYWQZ
  • UPC: 646437476362
  • Customer Reviews: 4.3 out of 5 stars

Our products are all manufactured in USA according to cGMP standards — requirements as defined in 21 CFR § 111 (current) Good Manufacturing Practices.

  1. SOURCING: The compounds are placed under quarantine as soon as they arrive at the facility.
  2. INGREDIENT ANALYSIS: The compound undergoes identity verification, microbial examination, and elemental impurity analysis; if any of these tests fail, the compound is immediately rejected.
  3. ENCAPSULATION & BOTTLING: The approved ingredients are mixed into an evenly distributed blend before being encapsulated and subsequently bottled.
  4. FINISHED PRODUCT ANALYSIS: Before release, the finished product is placed under quarantine until it has passed the same initial batch of tests and potency verification — this ensures that no contaminants have been introduced during the production process.

TEACRINE | Theacrine 100% Pure Bulk Powder

TeaCrine is ideal for anyone looking to increase their energy levels without increasing their heart rate or blood pressure. Theacrine (as TeaCrine) is the perfect non-stimulant compound that delivers powerful energy without the jitters or crash.*

  • ✅ TeaCrine is a unique compound that delivers energy, mental clarity, and improved motivation and mood.
  • ✅ 100% Pure TeaCrine Powder with zero fillers. Naturally has a strong bitter taste.
  • ✅ TeaCrine has a multi-pronged effect that is ideal for demanding athletes, driven professionals, gamers and anyone striving to attain peak performance. Based on extensive research, TeaCrine facilitates a wide range of healthy functions in energy, focus, mood and motivation.*
  • ✅ The perfect nootropic that can be taken with caffeine, such as coffee, for heightened effects that are safe and long lasting.*
  • ✅ TeaCrine does not “crash” like strong stimulants and provides stable energy & focus all day. It also is non-habit forming and does not create dependence.
  • Shipping Weight: 1.6 ounces 
  • ASINB01KD7CGWY
  • UPC: 733074122094

Indications

Energy, focus, motivation, nootropic, stimulant-free energy

Ingredients

TeaCrine

Directions

Take one serving of TeaCrine Tasteless anytime energy and focus are desired. Avoid taking within 6 hours of bed time.

Legal Disclaimer

Statements regarding dietary supplements have not been evaluated by the FDA and are not intended to diagnose, treat, cure, or prevent any disease or health condition.

TeaCrine Benefits

  • “Clean,” smooth mental energy and focus.
  • No jitters typically associated with caffeine.
  • Less tolerance buildup than caffeine.
  • No “crash,” habituation, or withdrawal issues usually seen with caffeine.
  • Anti-fatigue.
  • Elevated mood.
  • Greater motivation.
  • Much longer duration (half-life) than caffeine.
 

TeaCrine’s Mechanism of Action — How Does it Work?

Like its cousin caffeine, TeaCrine® seems to exert its effects by way of dopamine agonism (D1 and D2) and adenosine inhibition. Adenosine is a signaler of relaxation and tiredness. Specifically, though, TeaCrine®, like Dynamine®, purportedly only allosterically modulates adenosine receptor activity (A1 and A2a; decreases sensitivity), whereas caffeine directly antagonizes (blocks) adenosine receptors. This property results in less tolerance buildup for TeaCrine® compared to caffeine.

The CEO of Compound Solutions, Matt Titlow, explains this mechanism in the video below:

My TeaCrine Review

As suspected, TeaCrine® provided a long-lasting, clean, smooth energy and focus, not unlike a 1:1 caffeine-plus-theanine combination wherein theanine “smooths out” caffeine. One should be able to take 1 dose of TeaCrine® in the morning to last almost the entire 8-hour work day. Depending on your dopamine and adenosine sensitization, you may have to increase the dosage and/or combine with caffeine to make the effect last that long. Start small and work your way up.

There’s also definitely a perceptible synergistic effect with caffeine, as the research has shown. A subtle but important takeaway from that verified synergism is that it allows for the same EMF (energy, motivation, focus) enhancement with a lower dose of caffeine. There are plenty of benefits from that:

  • Increased EMF without hitting the threshold for the jitteriness and anxiety that accompany higher caffeine doses.
  • Less potential for tolerance buildup.
  • Less potential for caffeine withdrawal symptoms.
  • No caffeine “crash,” which is essentially just a rebound spike of adenosine.
  • Less stress on the cardiovascular system (potential for lower or no effect on blood pressure and heart rate)​13,14​.
  • Less effect on stress hormones like cortisol and noradrenaline.

Is TeaCrine Safe?

Recall that Taylor et al found no adverse effects on blood pressure, heart rate, lipid profiles, or liver and kidney biomarkers​6​. Other studies have confirmed these findings, and a later toxicological assessment of theacrine showed “the NOAEL for theacrine is considered to be 180 mg/kg bw/day in male and female Wistar rats.”​15​ NOAEL is the no-observed-adverse-effect-level.TeaCrine® received self-affirmed GRAS (Generally Regarded As Safe) status later that same year in 2016,Theacrine has an LD50 (dosage to kill 50% of the population) of 810.6 mg/kg in mice, which would equate to about 4 g for a human individual weighing 76 kg (168 lbs.)​2​.

As such, TeaCrine® is safe for human consumption at normal dosages.

TeaCrine Side Effects

Negative side effects from TeaCrine® are rare. People either seem to complain of being too stimulated – from combining TeaCrine® with caffeine and perhaps Dynamine® (remember, caffeine potentiates TeaCrine®) – or of difficulty falling asleep due to TeaCrine’s long half-life. For that reason, be sure to take TeaCrine® early in the day. Adding theanine to the mix should mitigate these unwanted effects.

TeaCrine Dosage

Most TeaCrine® supplements put the recommended dosage in the 100-300mg range, taken once daily. If taken with caffeine and/or Dynamine®, start small and work your way up.

TeaCrine Half-Life

TeaCrine® has an extremely long half-life that is thought to be around 20 hours, with effects tapering off and likely being imperceptible after about 6 hours. Onset of TeaCrine® happens around 1 hour after ingestion. Peak concentration occurs around the 1.5 hour mark.

TeaCrine Pre-Workout

TeaCrine® is useful as a pre-workout supplement if you’re looking to maintain that enhanced energy, focus, and motivation after your workout, since its effects last so long. This makes it perfect for someone who perhaps works out in the morning and then goes straight to work to tackle the day. Some popular pre-workout supplements that contain TeaCrine® include:

  • C4 Original from Cellucor
  • Embrace the Suck from Bare Performance Nutrition
  • Outlift Amped from Nutrex

TeaCrine Supplements

TeaCrine’s inherent properties and synergism with caffeine make it a good candidate for pre-workout supplements, fat burners, energy drinks, and nootropic blends, or simply by itself for a clean, smooth, all-day energy.

To run the “n=1” studies on myself when trying new compounds, I always think it’s imperative to try an ingredient in isolation first instead of within a blended supplement. Otherwise, how can you know you’re seeing a discernible effect from one ingredient?

Like Compound Solutions, Nootropics Depot (10% off with email signup) is all about research, quality, and transparency. I get most of my nootropics from them. They’re basically the gold standard in the supplement industry. They have a proven track record of providing the highest-quality research-backed ingredients with verifiable third-party analytical testing. They also happen to have great customer service and fast shipping. For a while now, they’ve been the antidote to the issues that have plagued the supplement industry and given it a bad reputation – label inaccuracy, questionable purity and safety, and lack of efficacy. In short, make sure you’re buying from a trusted seller and make sure you know what you’re getting. Nootropics Depot offers TeaCrine® in both capsule and powder form.

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