Uridine is a glycosylated pyrimidine-analog containing uracil attached to a ribose ring via a β-N₁-glycosidic bond. It is one of the five standard nucleosides which make up nucleic acids, the others being adenosine, thymidine, cytidine and guanosine.
Double Wood Supplements Uridine
- SUPPORTS CHOLINERGIC FUNCTION – Uridine promotes synthesis of brain phosphatidylcholine and helps to support cholinergic function.
- SUPPORTS BRAIN HEALTH – Uridine is a key building block used in the synthesis of RNA.
- PROMOTES SYNAPTIC CONNECTIONS – Uridine may help promote the synthesis of synaptic connections in the brain.
- MADE IN THE USA – Our Uridine is manufactured right here in the USA at a cGMP certified facility.
Uridine Monophosphate is an important building block used to create RNA, and increases synthesis of brain phosphatidylcholine. Studies have shown it may enhance the formation of synaptic connections, increase cholinergic brain function, and upregulate dopamine receptors.
When taken as a supplement it supports cognitive function and brain health.
Take 1-2 capsules (300-600mg) per day to support cholinergic brain function and formation of synaptic connections.
Uridine Monophosphate Capsules
Uridine (Uridine 5’-monophosphate) is a pyrimidine ribonucleoside nucleotide involved in phospholipid synthesis (1, 2).
Uridine Monophosphate Benefits
- Promotes increases in membrane phospholipid precursors
Uridine Monophosphate is emerging as a subject of interest in the medical community, but thus far, human studies, except for the one referenced above, are scarce.
The following are examples of dynamics associated with Uridine Monophosphate through the animal model and may not be representative of the effects in the human body:
- Enhances synthesis of CDP-choline (
- Promotes anti-inflammatory activity
- Promotes neural synapse formation (synaptogenesis)
Uridine Monophosphate Mode of Action
Uridine Monophosphate (UMP) is a nucleotide and substrate in the synthesis of CDP-Choline and its final conversion to phosphatidylcholine (PC) in the Kennedy cycle. CDP-choline is an essential nutrient and precursor to creating the neurotransmitter acetylcholine. Acetylcholine is a neurotransmitter in the parts of the brain that impact memory and learning, attention, and alertness–making it one of the most beneficial neurotransmitter compounds for overall cognitive function and brain health (3, 4). Common dietary sources of choline are animal-based products, dairy products, whole grains, cruciferous vegetables, nuts, and seeds (5).
CDP-Choline is an integral part of phospholipid synthesis (cell membrane formation) and increases brain energy through improved mitochondrial functions by maintaining the levels of phospholipids in mitochondrial membranes, restoring ATPase activity and preventing the release of arachidonic acid from cell membranes (an oxidative stress to the body) (3).
After choline is taken into the body, Uridine triphosphate (UTP) joins with the nucleotide Cytidine to produce CTP. CTP and the choline in the body, either from supplemental or dietary sources, come together to form Phosphocholine. Phosphocholine is then synthesized into CDP-Choline and is finally synthesized into Phosphatidycholine (6).
Uridine in the plasma is the only precursor to CTP available (7). Uridine monophosphate can also be found in fermented beer and breast milk; it is also supplemented in human infant formulas. Organ meats and cruciferous vegetables are theorized also to contain Uridine (4). After infancy, it is no longer consumed through mother’s milk or fortified formula but synthesized in the liver (7).
Uridine Triphosphate is necessary for the formation of Uridine Monophosphate. Uridine Triphosphate (UTP) phosphorylates Uridine and the nucleotide Cytidine together to form Uridine Monophosphate (UMP) (8). Uridine Monophosphate (UMP) is present in cellular cytoplasms, extracellular space, the endoplasmic reticulum, the Golgi apparatus, the lysosome, mitochondria, and the nucleus (1).
Uridine benefits neural synaptic function and promotes the creation of membranes and neuronal synapses and dendritic spines through its role in providing phosphatidylcholine, the final step in the choline pathway. As a result of increasing the phosphatidylcholine level in the brain (PC), neurons in the cholinergic pathway use the choline stored inside PC to synthesize Acetylcholine directly and increases the level of acetylcholine available in the brain (9).
Additionally, animal research has shown that the fish oil fatty acid DHA can increase levels of phosphatidylcholine (PC) in the brain by 30% when paired with Uridine (4).
Uridine Monophosphate Dosage
Pure Nootropics’ Uridine Monophosphate Capsules provide 250 mg per 1 capsule. Suggested use for adults is 2 capsules by mouth daily, or as recommended by your healthcare practitioner.
Uridine Monophosphate Side Effects and Toxicity
No adverse events were reported in the first clinical human study for Uridine Monophosphate (10).
If you are taking any medications, please consult your healthcare practitioner before beginning supplementation with Uridine Monophosphate.
Alpha GPC 600mg + Uridine, a Choline Enhancer
THE MOST BIOAVAILABLE CHOLINE SUPPLEMENT. Alpha GPC (choline alfoscerate) is the most bioavailable form of choline (40.3% choline), better than Phosphatidylcholine, CDP choline, Choline Bitartrate.
BETTER THAN ALPHA GPC OR URIDINE АLONE. Do you know that Uridine is a choline enhancer that works with Alpha GPC Choline synergistically to boost memory and overall cognitive function and that taking Alpha GPC and Uridine together works better than each on its own? Only Dr. Maxwell provides you with both in a single supplement*
ALPHA GPC IS THE MOST BIOAVAILABLE FORM OF CHOLINE. Choline sources differ in terms of choline content and absorption. The two most easily absorbed forms are Alpha GPC and CDP Choline, but Alpha GPC has double the choline content of CDP Choline (40.3% vs. 21.4%). PhosphatidylCholine and Choline Citrate have poorer absorption and lower choline content (13.7% and 37.4%), while Choline Bitartrate could lead to kidney and bladder stones*
DO YOU KNOW THAT IT IS IMPORTANT TO CHOSE SOY FREE ALPHA GPC EVEN IF YOU ARE NOT ALLERGIC TO SOY? Alpha GPC can be derived from lecithin from sunflowers or soy. The extraction process from sunflowers involves cold press, while from soy – harsh chemicals with harmful side effects. Soy lecithin may also cause bloating, diarrhea and nausea. This is why, unlike leading competitors, we provide soy free Alpha GPC from sunflower lecithin*
DID YOU NOTICE THAT NO OTHER BRAND CLAIMS IT LACKS INACTIVE INGREDIENTS OTHER THAN A VEGETABLE CAPSULE? That is because they can’t. Competitors contain nasty inactive ingredients that we would never consider: silicon dioxide, stearic acid, magnesium stearate, starch, maltodextrin or fillers as rice powder*
TWO SYNERGYSTIC INGREDIENTS AT THE PRICE OF ONE. Get the two ingredients Alpha GPC Choline and Uridine Monophosphate at the price of only one with Dr. Maxwell, saving at least 18$*
- Product Dimensions: 2.2 x 2.2 x 4.2 inches
- Shipping Weight: 2.4 ounces
- ASIN: B07XCNBNDF
Alpha GPC Choline, Uridine Monophosphate, Vegetable capsule
Take two capsules daily with food, preferably in the morning, or as directed by your physician. Do not exceed 4 capsules daily
Statements regarding dietary supplements have not been evaluated by the FDA and are not intended to diagnose, treat, cure, or prevent any disease or health condition. *This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
Statements regarding dietary supplements have not been evaluated by the FDA and are not intended to diagnose, treat, cure, or prevent any disease or health condition
NatureBell Uridine Monophosphate, Choline Enhancer, 350mg, 60 Capsules
Maximum Strength Uridine Capsules (Uridine 350mg, 60 Capsules). Made in USA.
Strongly Supports Cognitive Function, Neuronal Membranes, Mental Focus and Attention.
Uridine Monophosphate Capsule Uridine Capsule
- Uridine is a Key Building Block used in the Synthesis of RNA for Brain health.
- Non-GMO, No Gluten, No Soy, No Tree Nuts, No Artificial Colors, No Flavors and No Irradiation.
- 3rd Party Lab Tested and Made in California.
- Item Weight: 0.96 ounces
- Shipping Weight: 2.4 ounces
- ASIN: B01LBILGZW
- UPC: 642893344252
As a dietary supplement, take 500 mg one to three times daily. For best results, please consult your physician. Individual needs may vary.
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease. If pregnant/lactating or taking any medications, please consult your physician prior to use.
Statements regarding dietary supplements have not been evaluated by the FDA and are not intended to diagnose, treat, cure, or prevent any disease or health condition.
Read Uridine Monophosphate Reviews
To learn more, read the Uridine monophosphate reviews and experiences below.
What is Uridine Monophosphate?
Uridine monophosphate (UMP), also referred to as 5’-uridylic acid and uridine 5 monophosphate, is a nucleotide base that acts as a monomer in RNA. It is a chemical compound derived from phosphoric acid and the nucleoside uridine and is used in the body to increase the synthesis of cellular membranes. When consumed as a supplement, uridine monophosphate powder offers numerous potential benefits to your physical and cognitive health.
Uridine is one of the four main building blocks of RNA aside from adenosine, cytidine, and guanine. Adults create Uridine in their livers in the form of Uridine monophosphate, which is secreted into your blood. High levels of uridine can be found in beer as well as breast milk, various plants, and certain infant formulas. Uridine can also be found in the form of Uridine triphosphate. There are several Uridine monophosphate uses, and the body uses the compound in various processes, including signaling the creation of neurotransmitter synapses and promoting the repair of DNA and growth of cells.
Uridine Monophosphate Benefits and Uses
- May help promote cognitive function
- May help support healthy sleep patterns
- May help promote working memory
- May help support neurotransmission
Understanding Uridine Monophosphate
Uridine is believed to benefit synaptic functions by elevating phosphatidylcholine in the brain. Phosphatidylcholine is an important component of dendritic membranes. Uridine also plays a role as a substrate in phosphatidylcholine (PC) synthesis through the CDP-choline pathway, also known as the Kennedy cycle. Phosphatidylethanolamine is also synthesized via this pathway. This is significant since phosphatidylethanolamine is a phospholipid that contributes to building brain cell membranes and plays a huge role in neurotransmission.
In the Kennedy cycle, choline kinase catalyzes choline into phosphocholine consuming an ATP molecule during the process. This allows for more cellular choline to be converted into phosphocholine. Research on rodents found that rodents seemed to display improved cognitive function when consuming a diet containing a combination of uridine monophosphate, choline and docosahexaenoic acid (DHA). Other studies found a positive impact on cognition when subjects were taking a uridine dha stack, meaning taking a uridine supplement and a dha supplement together. Phosphatidylcholine is a phospholipid critical to synaptic function as well as beneficial to overall cellular health. Producing phosphatidylcholine requires CDP-choline, which requires uridine and cytidine. Conveniently, uridine can be converted into cytidine in the body.
Uridine Monophosphate Research
Uridine monophosphate presents a variety of potential benefits to the body and mind. Clinical trials on Uridine monophosphate discovered that Uridine monophosphate may promote improved memory and learning capabilities through the production of acetylcholine. Some research even suggests that Uridine monophosphate may promote the creation of new neural synapses. A larger number of neural synapses may potentially lead to greater mental capacity. Other Uridine monophosphate studies found that Uridine monophosphate has an effect on motivation, attention span, and a sense of well being.
Studies have shown that Uridine supplements may promote improved learning and memory abilities by increasing the production of acetylcholine, a prominent neurotransmitter. Uridine benefits may also include an increase in the formation of new neural synapses, which may point to greater mental capacity. Studies also suggest that Uridine monophosphate may improve spatial learning and attention span. Research believes that this may be a result of the compound’s effect on certain neurotransmitters, particularly neurotransmitters associated with mood, motivation, and attention span. Uridine benefits may also provide sleep support. Studies found that Uridine increased slow-wave, or deep, sleep in rats who had been sleep deprived. Preliminary studies show that slow-wave sleep is necessary to help the brain recover from its daily activities. Uridine monophosphate may also provide neuroprotection and improve the phospholipid content in your cell membranes.
Uridine Monophosphate Capsules Dosage
Scientific research has experimented with Uridine monophosphate dosage for years. However, as a dietary supplement, take one 250mg Uridine monophosphate capsule daily.
Where to Buy Uridine Monophosphate Capsules?
Nootropics Depot offers 60ct or 120ct jars of high quality Uridine monophosphate capsules (Disodium Salt). Nootropics Depot’s Uridine monophosphatehas been lab-tested and verified for both product purity and identity.
Attention: This product is not intended to diagnose, treat, cure, or prevent any disease. It has not been approved, nor have these statements been evaluated by the FDA.