Jiaogulan (Gynostemma) Supplement

Jiaogulan is a plant that grows wild in parts of Asia. The leaf is used to make medicine. Jiaogulan is sometimes referred to as “Southern Ginseng” because it grows primarily in south central China and is used in similar ways as ginseng.

People commonly use jiaogulan by mouth for high cholesterol, diabetes, liver disease, obesity, and many other conditions, but there is no good scientific evidence supporting most of these uses.

How does it work?

Jiaogulan contains substances that might help reduce cholesterol levels.

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Jiaogulan (Gynostemma) Capsules

Jiaogulan (Gynostemma Pentaphyllum) is an herb belonging to the gourd, melon, and cucumber family (1).  It is sometimes called “Southern Ginseng,” and although it is not a true ginseng, Jiaogulan does contain some of the compounds and benefits found in true ginseng (2).

Jiaogulan (Gynostemma) Benefits

  • May promote weight loss 

Jiaogulan (Gynostemma) is emerging as a subject of interest in the medical community, but thus far, there has not been a large amount of research or trials conducted with humans, except for those studies referenced above.*

The following are examples of dynamics associated with Jiaogulan (Gynostemma) through the animal model and may not be representative of the effects in the human body:

  • May lower blood glucose (in rats) 
  • May reduce oxidative stress (in rats)
  • May support cardiovascular health 
  • May support healthy levels of cholesterol (in animals)
  • Anti-inflammatory properties (in rat cells in vitro)

 Jiaogulan (Gynostemma) Mode of Action

Jiaogulan belongs to the family of Curcurbitaceae (which includes gourds, melons, and cucumbers) and is a climbing vine that produces a small purple, inedible gourd as its fruit.  It grows in China, Southeast Asia, Japan, Korea, India, Bangladesh and New Guinea.  It has serrated leaves which are grouped in arrangements of five and is sometimes referred to as “five-leaf ginseng” or “southern ginseng” (1).  Jiaogulan is not related to the ginseng family (2).

The leaves of Jiaogulan contain gypenosides, which are triterpene saponins.  Over 189 saponins can be found in Jiaogulan and some of the gypenosides are chemically identical to ginsenosides common to Panax ginseng.  Unlike Panax ginseng which contains the ginsenosides in the root, the aerial leaves of Jiaogulan contain its saponins, and are equal to the amount found in Panax ginseng’s roots (3).

Jiaogulan contains the ginsenosides Rb1, Rd, Rb3, and F2 which are present in Panax Ginseng (2).  The unique constituents of Jiaogulan include carotenoids, chlorophyll compounds, ombuine, allantoin, caffeic acid, vitexin, kaempferol, quercetin, rutin, selenium, calcium, magnesium, flavonoids, polysaccharides, sterols, malonic acid, lutein, linolenic acids, and palmitic acids (2, 3).

Though Jiaogulan has been present in traditional Chinese medicine, it has not been extensively studied in humans and further research is underway to discover all of its modes of action.

Scientists believe that Jiaogulan can increase fat oxidation and glucose uptake which may lead to weight loss because it is an activator of AMP-activated protein kinase.  The activation of the AMPK enzyme inhibits cholesterol and fat synthesis.  Both in vitro and in vivo research identified that the saponins damulin A and B are directly involved in this action by increasing the phosphorylation of AMPK, which in turn stimulates beta-oxidation (3).

Preliminary research suggests that Jiaogulan can reduce blood sugar levels through inhibition of protein tyrosine phosphatase 1B, which increases insulin sensitivity.  It is not believed to increase insulin in humans, but rather lowers blood glucose levels by increasing the release of insulin (3).

Jiaogulan’s gypenosides are thought to have anti-lipid peroxidation activities and may protect vascular endothelial cells from oxidative damage.  Its cardiovascular effects have been mostly studied in animals and suggests that its gypenosides may prevent the development of artherosclerosis, and may lower blood pressure, blood vessel resistance, heart rate, inhibit platelet aggregation, and increase coronary blood flow (3).

Perhaps the most interesting benefit of Jiaogulan is its ability to lower cholesterol.  In vitro and animal studies have pointed to the ability of Jiaogulan to activate liver X receptors, which are the receptors that regulate and sense the levels of cholesterol in the tissues.  By activating these receptors, the herb promotes balanced levels of cholesterol (3).

Jiaogulan’s anti-inflammatory properties are due to the gypenoside XLIX which inhibits the main pathway of inflammation through the nuclear factor-kappaB.  Gypenoside XLIX inhibits the activation of this pro-inflammatory due to a peroxisome proliferator-activated receptor-alpha-dependent pathway (PPAR-alpha-dependent) (3).

The extract of the roots via alcohol are generally used for concentrated saponin and triterpenoid content, while hot water extracts from the leaves in a tea are generally utilized for its flavonoids (2).

Jiaogulan (Gynostemma) Capsules Dosage

Pure Nootropics’ Jiaogulan (Gynostemma) Capsules provide 450 mg per 1 capsule.  Suggested use for adults is 1 capsule by mouth once daily.

Gynostemma Tea ( Jiaogulan Tea ) | Naturally Sweet Adaptogen | AMPK Metabolic Activator Herbal

The Chinese kept it secret for over 2000 years — Jiaogulan Leaf (gynostemma pentaphyllum)

  • 🌱🌱🌱 SUPERCHARGE YOUR METABOLISM with nature’s most POWERFUL AMPK ACTIVATOR – Gynostemma pentaphyllum (aka Jiao Gu Lan) is scientifically proven the best herbal tea for AMPK activation, (even more powerful than berberine or quercetin.) Brew with orange peel (natural source of hesperidin) for HEALTHY WEIGHT LOSS. Gynostemma is also a POTENT ANTI-INFLAMMATORY and herbalists consider it the KING OF NATURAL ADAPTOGENS. Naturally gravitate toward healthy cholesterol and blood sugar levels. *
  • 🌱🌱🌱 BOOST YOUR IMMUNE SYSTEM – Gynostemma leaves tea is often called SOUTHERN GINSENG, because it provides many of the same health benefits of ginseng. But, scientists were shocked to discover this herbal tea actually has 127 different saponins & gypenosides, that’s 7X the power of regular ginseng. Jiaogulan also stimulates increased SOD production, your body’s own powerful antioxidant. Higher SOD production is crucial for your body to generate new mitochondria. *
  • 🌱🌱🌱 NATURE’S MOST REVERED LONGEVITY HERB – The locals who grow this organic loose leaf tea actually call it – The Herb of Immortality. They’ve known for centuries the anti-aging effects of jiaogulan, aka gynostemma. Modern research backs up these claims showing that gynostemma is the best natural vasodilator, promoting blood flow and improved oxygen delivery. It’s an effective way to build a stronger cardiovascular system and better heart health. *
  • 🌱🌱🌱 THE BENEFITS ARE IN THE WHOLE LEAF! – Traditional Chinese Medicine and modern science agree, our bodies need the synergistic effects of full spectrum herbs. Pharmaceuticals and extracts are manufactured with chemistry, are less effective. Our gynostemma organic tea is pure 100% gynostemma pentahyllum leaf is naturally sweet and brews a bright green delicious caffeine free herbal tonic. We also offer gynostemma tea powder in capsule format, right here on Amazon
  • 🌱🌱🌱 OUR NAME MEANS JIAOGULAN – We founded Immortalitea in 2004 to introduce Jiaogulan to the world. We grow our loose leaf gynostemma 100% chemical and pesticide-free on small high altitude farms. We’re proud to have been the number one seller of Jiaogulan in the USA and Canada for over 13 years and standby all of our products with our peace of mind guarantee. If you are unsatisfied, for any reason, within 60 days of purchase, we’ll refund your order in full, no questions asked.

Ingredients
100% Gynostemma pentaphyllum

Directions
Add 1 tsp of loose tea to 8 fl oz of hot but not boiling water. Steep 2-3 minutes. Leaves may be re-steeped up to 3 times.

Legal Disclaimer
* Our products have not been evaluated by the United States Food and Drug Administration and are not approved to diagnose, treat, cure or prevent disease. The information provided is for informational purposes only and is not intended as a substitute for advice from your physician or other health care professional. Results may not be typical.

Statements regarding dietary supplements have not been evaluated by the FDA and are not intended to diagnose, treat, cure, or prevent any disease or health condition.

Jiaogulan 4100 mg Per Caps 200 Veggie Capsule

(Extract 10:1, Non-GMO & Gluten-Free) Gynostemma Pentaphyllum Supports Stamina and Endurance* Supports Immune System Health*

  • ✅ ✅ ✅ STRENGTH JIAOGULAN EXTRACT: NusaPure’s maximum strength Jiaogulan contains 4100mg per Caps of pure Jiaogulan extract (Extract 10:1). With 200 Veggie capsules in every bottle, you receive a full 200 day supply. Jiaogulan, also known as Gynostemma pentaphyllum, is a climbing vine indigenous to Japan, Vietnam, Southern Korea, and China. Jiaogulan is thought to have powerful antioxidant & adaptogenic properties. *
  • ✅ ✅ ✅ BENEFITS OF JIAOGULAN : Supports Stamina and Endurance *, Supports a Healthy Immune System *, Antioxidant Support *
  • ✅ ✅ ✅ MANUFACTURED IN THE USA: manufactured in a cGMP registered facility with the highest manufacturing and sourcing standards of NusaPure. Only natural items are used in the creation of this product. NusaPure is a trusted brand – recognized for our excellent customer service
  • ✅ ✅ ✅ STILL NOT SURE? DON’T WORRY! – As a small family business, we fully understand the uncertainty and risk of trying new supplements. And this is why we go extra mile to source only the highest quality ingredients. Also, trust and transparency is at the forefront of our brand. We list every single ingredient on our products so that you can make an informative decision. Let us know if you have any questions or if can be of any service!
  • ✅ ✅ ✅ COMMON NAMES & FORMS: Jiaogulan (Gynostemma pentaphyllum) is often referred to as Southern Ginseng. It is sometimes spelled Jiao Gu Lan, and comes in many forms including powder, capsule, veggie cap, tablet, pills, soft gel, herbal tea, or even whole leaf herb. Jiaogulan is widely regarded as an AMPK activator with antioxidant & adaptogenic properties. *

Safety Information
CAUTION: Do not exceed the recommended dose. Not intended for pregnant or nursing mothers. Not intended for children under 18 years of age. If you are taking any medications, have a known medical condition, or are planning a medical procedure, consult your doctor before use. Discontinue use and consult your doctor if any adverse reactions occur. *

Ingredients
Jiaogulan Extract 8200mg (Extract 10:1 per 2 capsules). Other Ingredients: Vegetarian Cellulose, Rice Powder, Silica, Magnesium Stearate (vegetable). CONTAINS NO: Artificial coloring, artificial flavor, preservatives, yeast, corn, milk or milk derivatives, lactose, salt, sodium, soy, sugar, gluten, starch or wheat.

Directions
For adults, take two (2) capsules daily, preferably with meals.

Legal Disclaimer
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Statements regarding dietary supplements have not been evaluated by the FDA and are not intended to diagnose, treat, cure, or prevent any disease or health condition.

Uses & Effectiveness?

Possibly Effective for

  • Diabetes. Drinking jiaogulan tea seems to reduce fastingblood sugar levels and improve how sensitive the body is to the effects of insulin in people with diabetes.
  • High cholesterol. Taking jiaogulan can decrease total cholesterol and increase the “good” high-density lipoprotein (HDL)/total cholesterol ratio in people with high cholesterol levels.

Insufficient Evidence for

  • Liver disease (nonalcoholic fatty liver disease). Taking jiaogulan by mouth does not seem to improve liver function, body mass index, cholesterol levels, kidney function, or blood sugar in people with a type of liver disease called nonalcoholic fatty liver disease.
  • Obesity.Taking jiaogulan by mouth seems to slightly decrease body weight in people who are obese.
  • Backache.
  • Bronchitis.
  • Cancer.
  • Constipation.
  • Gallstones.
  • Improving heart function.
  • Improving memory.
  • Pain.
  • Regulating blood pressure.
  • Stomach disorders.
  • Trouble sleeping (insomnia).
  • Ulcers.
  • Other conditions.

Side Effects & Safety

Jiaogulan is POSSIBLY SAFE when taken by mouth short-term (up to 4 months). In some people, it may cause side effects such as severe nausea and increased bowel movements.

Special Precautions & Warnings:

Pregnancy and breast-feeding: Jiaogulan is POSSIBLY UNSAFE when taken by mouth during pregnancy. One of the chemicals in jiaogulan has been linked to possible birth defects.
Not enough is known about the safety of jiaogulan during breast-feeding. Stay on the safe side and avoid use.
“Auto-immune diseases” such as multiple sclerosis (MS), lupus (systemic lupus erythematosus, SLE), rheumatoid arthritis (RA), or other conditions: Jiaogulan might cause the immune system to become more active. This could increase the symptoms of auto-immune diseases. If you have an auto-immune condition, it’s best to avoid using jiaogulan until more is known.
Bleeding disorders: Jiaogulan may slow blood clotting. There is a concern that it might make bleeding disorders worse.
Diabetes: Jiaogulan might cause blood sugar to become too low if taken by people with diabetes who are controlling their blood sugar with insulin or medications. Use with caution if you have diabetes.
Surgery: Jiaogulan might slow blood clotting. There is some concern that it might increase the risk of bleeding during and after surgery. Stop using jiaogulan at least 2 weeks before a scheduled surgery.

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