Magnesium Bisglycinate Chelate Capsules

Magnesium glycinate, also known as magnesium diglycinate or magnesium bisglycinate, is the magnesium salt of glycine, and is sold as a dietary supplement. It contains 14.1% elemental magnesium by mass. Accordingly, 100 mg of magnesium is contained in 709 mg of magnesium glycinate

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Magnesium Bisglycinate Chelate Capsules

Magnesium is an essential mineral and electrolyte responsible for supporting bone and heart health and participates in over 300 enzyme processes in the body. Magnesium is found in dietary sources–but a typical modern diet leaves approximately 68% of adults getting less than the recommended daily amount needed for the body’s processes (1).

Magnesium Bisglycinate Chelate Benefits

  • Supports bone health 
  • Promotes heart health 
  • Mood support 
  • Promotes sleep quality 

Magnesium Bisglycinate Chelate Mode of Action

Dietary sources of Magnesium include leafy green vegetables, legumes, beans, nuts, and animal meat (1).  Due to modern farming and soil quality, a mere 16% of the magnesium found in whole wheat stays intact after the refinement process, and most magnesium has been eradicated from drinking water (2).  In the United States, 19% of adults aren’t even consuming half of the Recommended Daily Allowance, with about 68% of adults still below recommended daily amounts (1).

In addition to bone health, heart health, and enzymatic function, Magnesium can also be used as a nootropic because of its abilities to support mood and sleep, specifically Magnesium Bisglycinate (sometimes referred to as Magnesium Diglycinate, or Magnesium Glycinate) (2, 3).

Magnesium Bisglycinate is a chelated amino acid where 2 glycine molecules (bisglycinate) are attached to the magnesium molecule.  The bisglycinate form is stable and avoids a breakdown in the gastrointestinal tract before it is completely absorbed. The bisglycinate chelate aids in mineral absorption because it is a small sized molecule and can be absorbed directly by intestinal cells (4). The bisglycinate form of the mineral has one of the highest bioavailable absorption (1).

Other forms of Magnesium such as oxide, citrate, aspartate, orotate, and L-Threonate are available, but Magnesium Biglycinate is gentle on the stomach because it is absorbed in different areas of the intestine than the others (1).

This form of Magnesium and glycine provides the benefits of glycine and magnesium together.  Glycine is a nonessential amino acid that is very important to metabolism and neurological health — glycine functions as a neurotransmitter in the nervous system and an antioxidant.  Glycine has been used to improve sleep quality in humans (5).

Research in animals suggests that Glycine’s ability to promote healthy sleep patterns is due to its ability to modulate body temperature and circadian rhythms through activating the NMDA receptors in the brain (6).

Pure Nootropics chooses to use the Magnesium Bisglycinate Chelate from TRAACS® by Albion Minerals for superior bioavailability.  TRAACS® by Albion is a certification that the mineral content is guaranteed to be an authentic chelated mineral amino acid (4).

Magnesium Bisglycinate contains 14.1% elemental magnesium, meaning that in 100 grams of Magnesium Bisglycinate, 14.1 g is elemental magnesium, and 86 g is glycine (7).  However, some supplement fact panels may already be adjusted to reflect this:  labels that say X amount of Magnesium Bisglycinate (as magnesium bisglycinate) mean that the milligrams listed are for the elemental magnesium provided in that dose.  Supplement fact panels that do not include these parentheses do not refer to the amount of elemental magnesium provided (8).

Pure Nootropics’ Magnesium Bisglycinate Chelate provides 150 mg of elemental magnesium per (2) capsules, as indicated on its label with the parentheses.

Magnesium Bisglycinate Chelate Dosage

Pure Nootropics’ Magnesium Bisglycinate Chelate provides 150 mg of elemental magnesium per (2) capsules.  Suggested use for adults is 2 capsules by mouth daily, or as directed by your healthcare practitioner.

The RDA (Recommended Daily Allowance) for Magnesium for adults 18-30 is: females 310 mg, males 410 mg; and adults 31 and older is: females 320 mg, males 420 mg (1).

Magnesium Bisglycinate Chelate Side Effects and Toxicity

Magnesium is generally well tolerated.  Side effects may include gastrointestinal symptoms such as nausea, vomiting, and diarrhea.  Magnesium toxicity does occur but is rare.  Renal insufficiency (kidney functions less than optimal) increase the possibility of consuming too much magnesium, called hypermagnesemia (9).

If you are taking any medications, please consult your healthcare practitioner before beginning supplementation with magnesium and to learn about any of the interactions which can occur.

The lethal dose of magnesium oxide for female rats was 3990 mg/kg; for male rats 3870 mg/kg; and for mice 810 mg/kg (10).

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Optimal Mood Complex Capsules

Pure Nootropics’ Optimal Mood Complex is formulated with a blend of herbal extracts, minerals, and amino acids to help support a calm and relaxed mood.

Optimal Mood Complex Benefits

  • Magnesium Bisglycinate Chelate promotes relaxation and mood support 
  • Zinc Bisglycinate Chelate supports positive mood 
  • Lemon Balm and Valerian Root Combination promotes a calm mood 
  • L-Theanine promotes a calm mood 

 Optimal Mood Complex Mode of Action

Magnesium Bisglycinate Chelate is a mineral which has sedative properties. The bisglycinate form of the mineral has the highest bioavailable absorption (1).  Its structure of a chelated amino acid means that there are 2 glycine molecules (bisglycinate) attached to the magnesium molecule.  The bisglycinate form is stable and avoids a breakdown in the gastrointestinal tract before it is completely absorbed.  It is also tolerated better and has less gastrointestinal side effects.  The bisglycinate chelate aids in mineral absorption because it is a small sized molecule and can be absorbed directly by intestinal cells.  Pure Nootropics chooses to use TRAACS® by Albion Minerals which is a certification that the mineral content is guaranteed to be an authentic chelated mineral amino acid for superior bioavailability (2).

Magnesium helps promotes a calm mood through its ability to promote relaxation and calm the nervous system (2).

Zinc Bisglycinate Chelate is a trace element which has a higher bioavailability than zinc gluconate and other forms of zinc supplements.  Its structure of a chelated amino acid means that there are 2 glycine molecules (bisglycinate) attached to the zinc molecule.  The bisglycinate form is stable and avoids a breakdown in the gastrointestinal tract before it is completely absorbed.  It is also tolerated better and has less gastrointestinal side effects.  The bisglycinate chelate aids in mineral absorption because it is a small sized molecule and can be absorbed directly by intestinal cells.  Pure Nootropics chooses to use TRAACS® by Albion Minerals which is a certification that the mineral content is guaranteed to be an authentic chelated mineral amino acid for superior bioavailability (2).

Zinc regulates neurotransmitter systems and a deficiency in zinc can result in mood disturbance (17).

Lemon Balm and Valerian Root Combination is a combination of the herbal extracts of Lemon Balm and Valerian root.

They are often used together because they exhibit synergy that may improve mood and sleep. Lemon Balm acts as a GABA transaminase inhibitor; GABA is broken down into Glutamate by GABA transaminase, so the inhibition of this enzyme frees up more GABA in the brain. Valerian stimulates GABA by stimulating glutamate decarboxylase; glutamate is converted into GABA with this enzyme.  The combination of Lemon Balm and Valerian is then able to stimulate the production of GABA within the brain by stimulating conversion of GABA and preventing the breakdown of GABA (4).  Activation of GABA within the brain promotes sleep (5).

L-Tryptophan is an essential amino acid which is converted in the body into serotonin (6).

L-Theanine is an amino acid which naturally occurs in tea leaves and some forms of mushrooms
(8).

L-Theanine promotes relaxation and improves sleep quality due to its ability to provide relaxation by increasing alpha-brain waves and regulating excitatory neurotransmitters that may inhibit a calm mood or restful sleep.  Alpha-brain waves (8-13 Hz) are the brain waves associated with relaxation and alertness and are produced within 30-40 minutes after ingestion.  The alpha-brain waves (or “a-waves”) occur in the occipital and parietal regions of the brain and prepare the body for a relaxed state prior to sleep (9,10).

Optimal Mood Complex Dosage

Pure Nootropics’ Optimal Sleep Complex was formulated based on researched and recommended dosages.

Pure Nootropics’ Optimal Mood Complex provides 30 mg Magnesium Bisglycinate Chelate, 25 mg Zinc Bisglycinate Chelate, 400 mg L-Tryptophan, 400 mg Valerian root extract (standardized to 0.8% valerenic acid), 100 mg Lemon Balm extract, 100 mg L-Theanine per (2) capsules.  Suggested use for adults is 2 capsules by mouth daily, or as directed by your healthcare practitioner.

Optimal Mood Complex Side Effects and Toxicity

As with any supplement, adequate research should be done regarding the ingredients and their use in combination. Always consider consulting with a healthcare practitioner if you have questions or concerns regarding supplement usage or dose.  Pure Nootropics’ Optimal Mood Complex was formulated based on researched and recommended dosages.

The most common side effects from taking this product may include daytime sleepiness, headaches, and dizziness.  However, as it is a product combining many effective supplements, we encourage you to check the side effects and possible interactions with any other medications or herbs or supplements that you may already be taking, as the list of side effects provided on this website is by no means complete and other side effects may occur based on individual reactions and interactions.

For further information, please see our References Tab above.

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Optimal Sleep Complex Capsules

Pure Nootropics’ Optimal Sleep Complex Plus is formulated with ingredients to help support healthy sleep patterns by promoting sleep quality and duration and may reduce the amount of time it takes to fall asleep.  Optimal Sleep Complex Plus encourages restful sleep and supports a refreshed mood when awakening.

Optimal Sleep Complex Benefits

  • Magnesium Bisglycinate Chelate promotes longer sleep times and falling asleep faster 
  • Zinc Bisglycinate Chelate promotes and regulates sleep quality 
  • Lemon Balm and Valerian Root Combination may promote better sleep quality 
  • L-Tryptophan may decrease the time it takes to fall asleep 
  • L-Theanine promotes sleep qualit
  • Melatonin may decrease time it takes to fall asleep 
  • Magnesium Bisglycinate Chelate, Melatonin and Zinc Combination may improve sleep quality, sleep times, and support a refreshed mood when awakening 

Optimal Sleep Complex Mode of Action

Magnesium Bisglycinate Chelate is a mineral which has sedative properties. The bisglycinate form of the mineral has the highest bioavailable absorption (1).  Its structure of a chelated amino acid means that there are 2 glycine molecules (bisglycinate) attached to the magnesium molecule.  The bisglycinate form is stable and avoids a breakdown in the gastrointestinal tract before it is completely absorbed.  It is also tolerated better and has less gastrointestinal side effects.  The bisglycinate chelate aids in mineral absorption because it is a small sized molecule and can be absorbed directly by intestinal cells.  Pure Nootropics chooses to use TRAACS® by Albion Minerals which is a certification that the mineral content is guaranteed to be an authentic chelated mineral amino acid for superior bioavailability (2).

Magnesium helps promote longer sleep times and falling asleep faster through its ability to promote relaxation and calm the nervous system (2).

Zinc Bisglycinate Chelate is a trace element which has a higher bioavailability than zinc gluconate and other forms of zinc supplements.  Its structure of a chelated amino acid means that there are 2 glycine molecules (bisglycinate) attached to the zinc molecule.  The bisglycinate form is stable and avoids a breakdown in the gastrointestinal tract before it is completely absorbed.  It is also tolerated better and has less gastrointestinal side effects.  The bisglycinate chelate aids in mineral absorption because it is a small sized molecule and can be absorbed directly by intestinal cells.  Pure Nootropics chooses to use TRAACS® by Albion Minerals which is a certification that the mineral content is guaranteed to be an authentic chelated mineral amino acid for superior bioavailability (2).

Zinc promotes and regulates sleep quality, but the entirety of the mechanisms behind its actions with regards to sleep is still being researched (3).

Lemon Balm and Valerian Root Combination is a combination of the herbal extracts of Lemon Balm and Valerian root.

They are often used together because they exhibit synergy that may improve sleep quality.  Lemon Balm acts as a GABA transaminase inhibitor; GABA is broken down into Glutamate by GABA transaminase, so the inhibition of this enzyme frees up more GABA in the brain. Valerian stimulates GABA by stimulating glutamate decarboxylase; glutamate is converted into GABA with this enzyme.  The combination of Lemon Balm and Valerian is then able to stimulate the production of GABA within the brain by stimulating conversion of GABA and preventing the breakdown of GABA (4).  Activation of GABA within the brain promotes sleep (5).

L-Tryptophan is an essential amino acid which is converted in the body into serotonin, which helps support healthy sleep patterns (6).  This mechanism may decrease the time it takes to fall asleep (7).

L-Theanine is an amino acid which naturally occurs in tea leaves and some forms of mushrooms
(8).

L-Theanine promotes sleep quality due to its ability to provide relaxation by increasing alpha-brain waves and regulating excitatory neurotransmitters that may inhibit restful sleep.  Alpha-brain waves (8-13 Hz) are the brain waves associated with relaxation and alertness and are produced within 30-40 minutes after ingestion.  The alpha-brain waves (or “a-waves”) occur in the occipital and parietal regions of the brain and prepare the body for a relaxed state prior to sleep (9,10).

Melatonin is a hormone made in the human body within the pineal gland, retina, bone marrow cells, and gastrointestinal tract.

Melatonin regulates circadian rhythms and may decrease sleep latency (or the time it takes to fall asleep).  Some research indicates that it reduces body temperature and that is mainly responsible for its ability to induce sleep.  Melatonin decreases with age, especially between 41 and 60 years of age (11).

Magnesium Bisglycinate Chelate, Melatonin and Zinc Combination combine the benefits of all 3 of these supplements and has been studied in this combination in humans.  This beneficial combination demonstrates the ability to promote healthy sleep patterns in adults (18, 19).

Optimal Sleep Complex Dosage

Pure Nootropics’ Optimal Sleep Complex was formulated based on researched and recommended dosages.

Pure Nootropics’ Optimal Sleep Complex provides 30 mg Magnesium Bisglycinate Chelate, 25 mg Zinc Bisglycinate Chelate, 400 mg L-Tryptophan, 400 mg Valerian root extract (standardized to 0.8% valerenic acid), 100 mg Lemon Balm extract, 100 mg L-Theanine, and 3 mg Melatonin per (2) capsules.  Suggested use for adults is 1 capsule by mouth for light rest, or 2 capsules by mouth for deeper sleep, or as directed by your healthcare practitioner.

Optimal Sleep Complex Plus Side Effects and Toxicity

You should consult with a health care practitioner before taking this product if you are taking any medications, herbs, or supplements.

As with any supplement or over the counter sleep aid, adequate research should be done regarding the ingredients and their use in combination. Always consider consulting with a healthcare practitioner if you have questions or concerns regarding supplement usage or dose.  Pure Nootropics’ Optimal Sleep Complex was formulated based on researched and recommended dosages.

For further information, please see our References Tab above.

Everything You Should Know About Magnesium Glycinate

Importance of magnesium

Magnesium is an important nutrient for the human body, because it’s part of many important processes that help maintain health, especially in your brain, heart, and muscles.

Research published in Nutrition ReviewsTrusted Source found magnesium deficiencies to be present in approximately 50 percentTrusted Source of people in the United States. The recommended magnesium dose varies depending on:

  • age
  • gender
  • physiological conditions, such as pregnancy and nursing

According to research published by the American Physiology Society, magnesium supplements have been shown to help with:

  • migraine
  • anxiety
  • chronic pain
  • heart disease
  • diabetes

One of the supplements often used for deficiency of this nutrient is magnesium glycinate, which is magnesium bound to glycine. This type of supplement has very good absorption levels. That means your body can make the most of it once it’s ingested.

The benefits of magnesium glycinate

Magnesium glycinate has been shown to have a variety of benefits, including the following:

  • It has a calming effect on your brain due to the presence of glycine.
  • It can help relieve anxiety and promote better sleep.
  • It helps keep bones strong by maintaining healthy bone density.
  • It helps control blood sugar in people with diabetes and may lower the risk of developing diabetes.
  • It decreases abnormal heart rhythms.
  • It reduces premenstrual syndrome (PMS) symptoms.

Given its gentle yet beneficial effect on the body, magnesium glycinate can be used to treat a variety of conditions. According to a study published in the Journal of Pain and Relief, these include:

  • chronic pain
  • overall muscle flexibility
  • quality of life in general

Certain conditions or risks improve with magnesium supplementation such as:

  • fibromyalgia, according to a study published in Rheumatology InternationalTrusted Source
  • chronic fatigue syndrome, as reported in a study in BMC Complementary and Alternative MedicineTrusted Source
  • risk of stroke, heart failure, diabetes, and all-cause mortality, according to a study in BMC Medicine
Magnesium deficiency

Most people in the United States consume less magnesium than they should. Dosages recommended by the American Physiological Society are 420 milligrams (mg) for men and 320 mg for women.

Symptoms of magnesium deficiency may include:

  • loss of appetite
  • nausea
  • fatigue
  • tingling and muscle cramps and contractions
  • abnormal heart rhythms
  • damage to nerve cells, which can lead to depression

Magnesium deficiency can cause other mineral deficiencies, as all minerals work together at keeping the body healthy.

How to use magnesium glycinate supplements

Magnesium glycinate is available in capsules containing 120 mg or 125 mg. The recommended dose is 320 mg for women and 420 mg for men per day, which means taking up to four capsules unless otherwise advised. If you take four capsules a day, take them two at a time twice a day with food, and together with a vitamin B complex supplement to improve absorption.

You may notice improvement in health conditions as early as a week after taking supplements. Depending on the severity of your deficiency or your particular medical condition, it might take as long as six months to see results.

Caution: Some drugs can cause your body to eliminate extra magnesium, which can lead to deficiencies. Talk to your doctor if you’re taking any medication. As well, your supplement might interfere with numerous medications.

Excess magnesium

In general, excessive levels of magnesium aren’t common in healthy people because the kidneys will eliminate the excess. If you want to track your magnesium intake while taking supplements, you can keep tabs on the magnesium content of various foods that you eat.

Some of the symptoms of excess magnesium include:

  • hypotension, or low blood pressure
  • nausea
  • vomiting
  • facial flushing
  • irregular heartbeat
  • difficulty breathing
Natural sources of magnesium

Magnesium is found in large amounts in natural, unprocessed foods. The best sources of magnesium include foods that contain dietary fiber, such as:

  • dark green, leafy vegetables, such as Swiss chard and spinach
  • nuts and seeds, such as pumpkin and sesame seeds
  • seaweed
  • beans and lentils
  • whole, unrefined grains
  • fish, especially halibut

Try to have your daily meals include a variety of fresh vegetables and fruit. Keep in mind that only 30 to 40 percent of magnesium ingested from food sources is absorbed and used by your body.

Opt for foods grown in healthy soils that are local and organic, if possible. These soils contain the highest concentration of nutrients and minerals, including magnesium. Produce is often grown in soils that miss important nutrients. As a result, some fresh produce may lack minerals, including magnesium.

Risks of taking magnesium glycinate

Although magnesium supplementation is generally considered safe for healthy adults, be sure to take these precautions:

  • Consult with your doctor when you start taking magnesium glycinate for the most appropriate daily dose.
  • When choosing a supplement, always check the amount of elemental magnesium present. This information is usually present on the information label.
  • Buy supplements from a respected source. Vitamins and supplements aren’t monitored by the U.S. Food and Drug Administration.
  • Consult with your doctor if you have any heart or kidney problems.
  • If you’re taking antibiotics or other medications, ask your doctor how they will interact with magnesium, and whether absorption of either the magnesium or the medications will be affected.
The bottom line

Magnesium is an important mineral that helps your body function properly, especially your muscular system, bones, and nervous system.

You can get a lot of your magnesium from your daily diet by including a variety of green leafy vegetables, beans and lentils, and seeds and nuts.

If you can’t get enough magnesium from diet alone, supplementation with magnesium glycinate is a gentle and efficient way of introducing additional magnesium into your body.

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