Top Nicotinamide Mononucleotide Supplements
- SUPPORTS HEALTHY AGING – Studies have shown NMN supports DNA repair and supports the SIRTUN genes that have been linked with healthy aging.
- SUPPORTS ENERGY METABOLISM – Research has shown NMN may support age-related bodily energy production.
- SUPPORTS NAD+ PRODUCTION – NMN is orally bioavailable and has been shown to support levels of NAD+ in the liver and muscle tissue.
- MADE IN THE USA – Our Nicotinamide Mononucleotide is manufactured right here in the USA at a cGMP certified lab.
Nicotinamide Mononucleotide (NMN) is a naturally occurring metabolite that can be found in small amounts in the human body and is found in small amounts in some foods. NMN has been found to be very orally bioavailable, and to support NAD+ levels within liver and muscle tissue.
Recent research has suggested that NMN may support healthy heart function, bodily energy production, brain health, and well as eye and bone health. One of the most exciting findings of NMN research is that it may support DNA repair and promote the SIRTUIN genes which are believed to play a role in healthy aging.
The generally recommended dosage of Nicotinamide Mononucleotide is anywhere between 250 – 1500 mg per day. As this is an expensive compound to produce and cost is an issue for many people, we recommend a dosage of 250 – 500 mg per day.
NMN is absorbed extremely quickly and has a short half-life, so to keep NAD+ levels high for as much of the day as possible it’s recommended to take one 125 mg capsule on waking and another in the afternoon if taking 250 mg per day.
If taking a higher dose, you’d want to take one 125 mg capsule in the morning and continue to take more an additional capsules every 1-3 hours depending on the total dose you’re aiming for.
Nicotinamide Mononucleotide Side Effects
While Nicotinamide Mononucleotide is a fairly new supplement and research is ongoing, studies performed so far have shown it to be very safe and non-toxic.
Side effects are rare, but itchiness, dizziness, sweating, and nausea have been reported in some cases. Please consult your physician before taking NMN.
NMN is a NAD+ precursor which supports healthy aging.
- Passed initial safety study in first clinical trial in humans 11/2019
Nicotinamide Mononucleotide (NMN) is emerging as a subject of interest in the medical community, but thus far, there has not been research or trials conducted with humans, except for the studies referenced above.*
The following are examples of dynamics associated with NMN through the animal model and may not be representative of the effects in the human body:
- Protects the brain’s blood vessels during aging (in mice)* Cerebromicrovascular circulation is associated with healthy cognition during aging.
- Increases telomere length (in mouse liver cells) Telomeres are the ends of chromosomes which shorten with age.
- Increases sirtuin1 gene activity (in mice) Sirtuins are molecules which reduces cellular damage and aging.
Mechanism of Action
Nicotinamide Mononucleotide (NMN) is a nucleotide which is a precursor to NAD (Nicotinamide adenine dinucleotide). NAD is a cofactor found in all living cells and is necessary for cellular reactions. NAD carries electrons between reactions and exists in an oxidized form (NAD+) or a reduced form (NADH)
Maintaining higher levels of NAD increases levels of the energy molecule, ATP, and is vital to DNA repair, gene expression, and signaling between cells. Lower levels of NAD are associated with aging and age-related degeneration
Many NAD precursors are available as supplements to increase levels of NAD in the body. Each precursor has a unique pathway which usually involves breaking down into Nicotinamide Riboside (NR). NR is a type of Vitamin B3 . Like NR, Nicotinamide Mononucleotide can be found in some food sources, but only in trace amounts. These food sources include broccoli, cabbage, cucumbers, tomatoes, avocados, and edamame
It was previously believed that NR was the only NAD precursor that could enter the cell, and that supplementing with NR was a more direct way to synthesize NAD. Generally, NMN requires an extra step which converts NMN into NR before entering the cell and then is converted back into NMN through another phosphorylation process .
However, scientists recently discovered that a membrane protein (Slc12a8) is specific for NMN transport directly across the cell membrane and into the cell. This protein requires sodium in order to transport the NMN
The majority of the cells which NMN enters can be found in the pancreas, small intestine, liver, and adipose tissue (fat tissue). NMN can be found in the bloodstream as quickly as 5 minutes after being absorbed from the small intestine in mice, and it is distributed into the body tissues quickly thereafter and converted into NAD
NMN has advantages over other NAD precursors, specifically regarding Sirtuin interactions
NMN is currently being studied for its effects in humans, though most of the studies on NAD prcursors in humans have been conducted with NR. The scientific research for NMN that is plentiful involves animal studies; however, NMN’s safety profile in humans was recently released in November, 2019 and appears to be a feasible supplement for humans
As stated above, NMN’s complete safety profile in humans is being investigated.
In mice, administering a very high dosage (that is much higher than the recommended human dosage) over a period of a year did not cause any side effects or toxicity. Due to the short lifespan of mice (approximately 2 years), the administration of NMN over 1 year has been likened to administration equal to half their lives