Royal Jelly Health Benefits

Royal jelly is a gelatinous substance produced by honey bees to feed the queen bees and their young.

It’s frequently sold as a dietary supplement to treat a variety of physical ailments and chronic diseases.

While it has long been used in traditional medicine, its applications in Western medicine remain controversial.

Here are 12 potential benefits of royal jelly.


Royal Jelly Capsules

Produced by worker bees, Royal Jelly is a nutritious jelly also known as a superfood due to the protein, carbohydrates, fatty acids, free amino acids, sugars, minerals, and vitamins (1)(2).

Royal Jelly Benefits

  • Promotes glucose tolerance
  • Mood support 
  • Promotes red blood cell production 
  • Supports male sexual health 

Royal Jelly is emerging as a subject of interest in the medical community, but thus far, there have not been many studies conducted with humans.

The following are examples of dynamics associated with Royal Jelly through the animal model and may not be representative of the effects in the human body:

  • Supports cognitive function (in mice) 

Royal Jelly Mode of Action

Royal Jelly is a secretion from the salivary glands (hypopharyngeal and mandibular glands) of the worker honey bees which is used as the queen bee’s food (2).  Queen bees ingest royal jelly for the duration of their lives, unlike the other adult bees.  Royal jelly is often fed to the queen larvae and young larvae of the other bees (1).

Royal Jelly consists of several nutrients which include lipids (80-85% of the total content is fatty acids), dietary fatty acids (such as 10-HDA which is unique to royal jelly and consists of 32% of content), peptides57-kDa protein (unique to queen bees), carbohydrates (at 10-16% volume by weight), mineral saltsacetylcholineAdenosine Triphosphate (ATP), and testosterone (1).

A lyophilized (freeze-dried) concentrate increases the bioavailability of royal jelly for humans.  Due to the varying composition of royal jelly due to season and cultivation, the macronutrient composition of royal jelly varies (1).

The areas in which Royal Jelly has been studied in humans have the greatest promise is in glucose metabolism, both in humans and in vitro (3, 4). The information on Royal Jelly supplementation in humans is scarce.  Several animal studies have shown some promise in the areas of longevity but the studies were conducted on nematodes (worms) which may not be representative as to the effects in the human body (5).

Royal Jelly Dosage

Pure Nootropics’ Royal Jelly provides 500 mg of 6-10% HDA freeze-dried concentrate which is equivalent to 1500 mg of fresh Royal Jelly per 1 capsule.  Suggested use for adults is 1 capsule daily, or as directed by your healthcare practitioner.

Royal Jelly Side Effects and Toxicity

If you are taking any medications, always consult with you Healthcare Practitioner before beginning any new supplement.

Toxicology studies in rats at doses equivalent to human doses of 86-89 mg/kg did not produce any toxicity (1).

Puritan’s Pride Royal Jelly 500 mg-120 Softgels

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This product has been made with the highest quality ingredients available
Over 40 years in business and 19 million customers served

From Ashwagandha to Zinc and everything in between, Puritan’s Pride has the nutritional supplements you need to support your individual health and wellness journey. Our extensive assortment aims to address every aspect of a healthy lifestyle.

For over 45 years, Puritan’s Pride has been trusted by generations of families as their health and wellness partner. Our mission has always been to provide the highest quality nutritional supplements.

Puritan’s Pride vitamins, minerals and supplements are scientifically formulated using the highest quality ingredients from around the world. We manufacture our supplements right here in the U.S.A., rigorously testing and inspecting them up to 15 times to ensure purity, potency, and consistency in every bottle.

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Statements regarding dietary supplements have not been evaluated by the FDA and are not intended to diagnose, treat, cure, or prevent any disease or health condition.

NOW Supplements, Royal Jelly 1000 mg with 10-HDA (Hydroxy-D-Decenoic Acid), 60 Softgels


  • SUPERFOOD: Royal jelly has a complex nutritional profile that includes nucleotides, polyphenols, and unique organic acids. It has been used traditionally since ancient times as a health tonic. Take 1 softgel 1 to 2 times daily.
  • 1000 mg EQUIVALENCY/14 mg 10-HDA: NOW Royal Jelly has been freeze-dried to maintain maximum stability and is among the finest products available. 10-HDA (hydroxy-d-decenoic acid) is one of the active, measurable components of royal jelly.
  • CLASSIFICATIONS/CERTIFICATIONS: Non-GMO, Kosher contains Gelatin, Soy Free, Dairy Free
  • GMP Quality Assured: NOW closely adheres to both mandatory U.S. FDA Current Good Manufacturing Practices (CGMP) regulations and voluntary Natural Products Association (NPA) Good Manufacturing Practices (GMP) regulations. Good manufacturing practices ensure compliance with sanitation, processing, documentation, and testing requirements that are designed to promote consistent, highly reproducible product quality and safety.
  • Packaged in the USA by a family owned and operated company since 1968

Safety Information
For adults only. Keep out of reach of children. Consult your physician if pregnant or nursing, taking any other medication, or have a medical condition. Do not eat freshness packet. keep in bottle. Store in cool and dry place after opening. Notice: Natural color variation may occur in this product. Allergen Caution: Product not manufacture with wheat, gluten, soy, milk , egg, fish, shellfish or tree nut ingredients. Produced in a GMP facility that processes other ingredients containing these

Supplement Facts Serving Size: 1 Softgel Servings Per Container: 60 Description Amount per Serving % Daily Value * Percent Daily Values are based on 2,000 calorie diet.† Daily Value not established. Calories 5 Royal Jelly (14 mg 10-HDA)(a 3.3:1 freeze-dried concentrate equivalent to1000 mg of fresh Royal Jelly)

Take 1 softgel 1 to 2 times daily.

Legal Disclaimer
These statements have not been evaluated by the Food & Drug Administration. This products is not intended to diagnose, cure, mitigate, treat, or prevent any disease.

Statements regarding dietary supplements have not been evaluated by the FDA and are not intended to diagnose, treat, cure, or prevent any disease or health condition.

12 Potential Health Benefits of Royal Jelly

1. Contains a Variety of Nutrients
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Royal jelly is comprised of water, carbs, protein and fat (1).

The full chemical makeup of royal jelly is unknown, but its positive effects on health are thought to stem from its unique proteins and fatty acids (1, 2Trusted Source).

These include nine glycoproteins collectively known as major royal jelly proteins (MRJPs) and two fatty acids, trans-10-Hydroxy-2-decenoic acid and 10-Hydroxydecanoic acid (2Trusted Source).

Royal jelly also contains several B vitamins and trace minerals.

However, nutrient composition varies considerably between sources of royal jelly (1).

Some of the vitamins typically present in royal jelly include:

  • Thiamine (B1)
  • Riboflavin (B2)
  • Pantothenic acid (B5)
  • Pyridoxine (B6)
  • Niacin (B3)
  • Folic acid (B9)
  • Inositol (B8)
  • Biotin (B7)

These nutrients may provide some of royal jelly’s potential health benefits, though more research on this unique substance is needed.

SUMMARYRoyal jelly contains water, carbs, protein, fat, B vitamins and trace minerals. Its unique proteins and fatty acids may be the reason for its potential health benefits.
2. May Provide Antioxidant and Anti-Inflammatory Effects

Royal jelly is widely claimed to reduce inflammation and oxidative stress.

In multiple test-tube and animal studies, specific amino acids, fatty acids and phenolic compounds found in royal jelly appear to have potent antioxidant effects (3Trusted Source).

Additionally, several test-tube studies show reduced levels of pro-inflammatory chemicals released from immune cells treated with royal jelly (4Trusted Source, 5Trusted Source, 6Trusted Source).

While these results are promising, human studies are lacking. More data is needed to draw any definitive conclusions on treating inflammation with royal jelly.

SUMMARYSome animal and test-tube studies indicate royal jelly may have antioxidant and anti-inflammatory effects. However, comprehensive research does not exist.
3. May Reduce Heart Disease Risk by Impacting Cholesterol Levels

Both animal and human studies demonstrate that royal jelly may positively impact cholesterol levels and thereby reduce heart disease risk.

Though the exact mechanism remains unclear, specific proteins in royal jelly may help lower cholesterol (7Trusted Source).

One 12-week study found that rabbits supplemented with royal jelly significantly reduced their total and “bad” LDL cholesterol levels by 28% and 23%, respectively (8Trusted Source).

Similarly, a one-month human study saw an 11% and 4% reduction in total and “bad” LDL cholesterol levels in people taking about 3 grams of royal jelly daily (9Trusted Source).

Conversely, another small human study determined no significant differences in cholesterol levels between participants treated with royal jelly and those on a placebo (10Trusted Source).

While these studies are promising, more research is needed to better understand royal jelly’s impact on heart health.

SUMMARYSome animal and human research has shown reduced cholesterol levels with royal jelly supplements. However, more studies are needed to confirm these results
4. May Aid Wound Healing and Skin Repair
Royal jelly —ng and Skin Repair both used orally and topically — may support wound healing and other inflammatory skin conditions.

It’s known to have an antibacterial effect, which can keep wounds clean and free from infection (11Trusted Source).

One animal study revealed an increase in collagen production in rats given royal jelly extract. Collagen is a structural protein vital for skin repair (12Trusted Source).

A test-tube study showed significantly enhanced tissue repair capacity in human cells treated with royal jelly (13Trusted Source).

Conversely, a more recent human study did not notice any difference in wound healing between a control group and participants treating diabetic foot ulcers topically with royal jelly (14Trusted Source).

Ultimately, more research is needed on royal jelly’s effects on wound healing and tissue repair.

SUMMARYSome research indicates that royal jelly may enhance production of proteins involved in tissue repair. However, more research is needed.
5. Specific Proteins May Lower Blood Pressure

Royal jelly may protect your heart and circulatory system by reducing blood pressure.

Several test-tube studies indicate that specific proteins in royal jelly relax smooth muscle cells in your veins and arteries, thereby lowering blood pressure (15Trusted Source).

A recent animal study examined a supplement combining royal jelly with other bee-derived substances and found a significant reduction in blood pressure. However, the exact role royal jelly played in this supplement is unclear (16Trusted Source).

More research is needed to understand royal jelly’s relationship with blood pressure.

SUMMARYWhile early research indicates that specific proteins in royal jelly may lower blood pressure, more research is needed.
6. Regulates Blood Sugar by Reducing Oxidative Stress and Inflammation

Royal jelly may also improve blood sugar control and insulin sensitivity by reducing oxidative stress and inflammation.

Multiple animal studies showed increased insulin sensitivity and an apparent protective effect on pancreatic, liver and reproductive tissue in obese, diabetic rats treated with royal jelly (17Trusted Source, 18Trusted Source, 19Trusted Source).

One small six-month human study demonstrated a 20% reduction in fasting blood sugar in healthy people who supplemented daily with royal jelly (10Trusted Source).

However, research on this topic is limited.

SUMMARYMultiple animal studies indicate that royal jelly may increase insulin sensitivity and improve blood sugar control. However, human-based research is limited.
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7. Antioxidant Properties May Support Healthy Brain Function

Royal jelly may boost brain function.

One study revealed that stress-induced mice treated with royal jelly had lower levels of stress hormones and a more robust central nervous system than the control group (20Trusted Source).

A separate study resulted in improved memory and reduced symptoms of depression in postmenopausal rats given royal jelly (21Trusted Source).

Another animal study showed that rats treated with royal jelly were better able to remove certain chemical deposits in the brain associated with Alzheimer’s disease (8Trusted Source).

Most of these studies attribute the protective effect on brain and nervous tissue to royal jelly’s antioxidant capacity.

Though this data is encouraging, human research is needed.

SUMMARYMultiple animal studies indicate that royal jelly may benefit brain function, though human research is lacking.
8. May Increase Tear Secretion And Treat Chronic Dry Eyes

Royal jelly may treat dry eyes when taken orally.

One animal and one small human study showed improvements in chronic dry eyes for those treated orally with royal jelly. The results indicate that this bee-derived substance may increase tear secretion from lacrimal glands within your eyes (22Trusted Source, 23Trusted Source).

No adverse effects were reported from the human study. Thus, royal jelly could serve as a low-risk solution for chronic dry eyes.

Keep in mind that this very small data sample doesn’t indicate that royal jelly is able to treat most people’s dry eyes. Ultimately, more research is needed.

SUMMARYA small amount of data shows that royal jelly may increase tear secretion in people with chronic dry eyes. However, further studies are necessary.
9. May Provide Anti-Aging Effects Through Various Means

Royal jelly may slow the aging process in several ways.

A few studies show increased lifespan and improved cognitive performance in rats treated orally with royal jelly (24Trusted Source).

Royal jelly is sometimes included in topical skin care products to support maintenance of healthy, younger-looking skin.

Animal research indicates that royal jelly may support increased collagen production and protection from skin damage associated with UV radiation exposure (12Trusted Source, 25Trusted Source).

Since human research on the anti-aging benefits of oral or topical royal jelly use is insufficient, more studies are needed.

SUMMARYRoyal jelly may reduce some common symptoms of aging, but research is lacking.
10. May Support a Healthy Immune System

Royal jelly may enhance your body’s natural immune response to foreign bacteria and viruses (26Trusted Source).

MRJPs and fatty acids in royal jelly are known to promote antibacterial activity, which can reduce incidence of infection and support immune function (11Trusted Source).

However, most applicable data is limited to animal and test-tube research. Therefore, more human studies are needed to confirm these effects.

SUMMARYSome animal and test-tube research supports antimicrobial effects of royal jelly and indicates this substance may boost your immune system. However, human studies are lacking.
11. Reduces Side Effects of Cancer Treatment

Chemotherapy and other cancer treatments come with significant negative side effects, including heart failure, inflammation and gastrointestinal (GI) issues.

Royal jelly may reduce some of the negative side effects associated with certain cancer treatments.

One study revealed a significant reduction in chemotherapy-induced heart damage in rats supplemented with royal jelly (27Trusted Source).

One very small human study indicated that topically applied royal jelly may prevent mucositis, a cancer treatment side effect that causes painful ulcerations in your digestive tract (28Trusted Source).

Though encouraging, these studies don’t offer definitive conclusions regarding royal jelly’s role in cancer treatment. More research is warranted.

SUMMARYRoyal jelly may treat certain side effects caused by cancer treatment. However, more research is needed.
12. May Treat Certain Symptoms of Menopause

Royal jelly may also treat symptoms associated with menopause.

Menopause causes a reduction in circulating hormones that is associated with physical and mental side effects, such as pain, impaired memory, depression and anxiety.

One study found royal jelly effective at reducing depression and improving memory in postmenopausal rats (21Trusted Source).

Another study in 42 postmenopausal women noticed that supplementing daily with 800 mg of royal jelly for 12 weeks was effective in reducing back pain and anxiety (29Trusted Source).

Keep in mind that more research is needed.

SUMMARYRoyal jelly may effectively treat menopause symptoms, though more research is needed.
Dosage and Supplement Forms

Because research is relatively limited, a definitive recommended dosage for royal jelly hasn’t been established.

When taken as a dietary supplement, royal jelly is available in its natural state — a gel-like substance — or in powder or capsule form.

Benefits have been observed in a wide range of dosages. Current research supports possible benefits at 300–6,000 mg per day (30).

Royal jelly can also be applied topically to your skin and is sometimes included in commercially available skin care products.

If you’ve never used royal jelly before, it’s best to start with a very small dose to avoid serious allergic reactions and side effects.

SUMMARYThere is no official recommended dosage for royal jelly. Current research indicates possible benefits at 300–6,000 mg per day.

Risks and Side Effects

Though probably safe for most, royal jelly is not without risks.

Because it’s a bee product, people with allergies to bee stings, pollen or other environmental allergens should exercise caution.

Some environmental contaminants, such as pesticides, have also been found in royal jelly and could lead to allergic reactions (2Trusted Source).

While using royal jelly is likely safe for most people, serious adverse reactions have occasionally been reported. These include (2Trusted Source):

  • Asthma
  • Anaphylaxis
  • Contact dermatitis

Some of these extreme reactions could even be fatal.

SUMMARYThough generally considered safe, royal jelly may lead to serious allergic reactions.

The Bottom Line

While royal jelly has been used in ancient medicinal practices for centuries, it has been largely rejected by Western medical practitioners due to a lack of research.

Nonetheless, this bee product — which is different than honey — is still frequently used as an alternative treatment for a variety of physical and mental ailments.

To date, many of the health claims associated with royal jelly remain unproven. The bulk of available research is limited to animal and test-tube or very small human studies.

Ingesting royal jelly is not 100% risk-free. Serious side effects such as anaphylaxis have occasionally been reported.

Though current research is promising, more research is needed to determine how royal jelly may fit into a healthy lifestyle.

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